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IgG4 immunodeficiency.

¹Division Immunology and Allergy, Harbor-UCLA Medical Center, Torrance 90509.

New England and Regional Allergy Proceedings

|January 1, 1988

Summary

This summary is machine-generated.

Isolated immunoglobulin G4 (IgG4) deficiency, a condition sometimes linked with other IgG subclass deficiencies, frequently leads to pyogenic infections, particularly respiratory tract infections. This deficiency is also associated with chronic diarrhea, asthma, food sensitivities, and autoimmune disorders.

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Area of Science:

Immunology
Clinical Medicine

Background:

Immunoglobulin G4 (IgG4) deficiency can be isolated or co-occur with other IgG subclass deficiencies (IgG2, IgA, IgG1).
Isolated IgG4 deficiency presents with symptoms mirroring other IgG subclass deficiencies, primarily recurrent pyogenic infections.

Purpose of the Study:

To describe the clinical manifestations and diagnostic considerations of isolated IgG4 deficiency.
To present reference ranges for serum IgG4 levels in children and adolescents.

Main Methods:

Analysis of clinical data from patients with IgG4 deficiency.
Determination of mean and normal ranges of serum IgG4 in 400 subjects (4 months to 17 years).

Main Results:

Isolated IgG4 deficiency is commonly associated with recurrent pyogenic infections, especially respiratory infections.

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Increased prevalence of IgG4 deficiency observed in individuals with chronic diarrhea, asthma, food allergies, chronic candidiasis, pediatric AIDS, and autoimmune disorders.

Conclusions:

Isolated IgG4 deficiency is a significant risk factor for pyogenic infections and is linked to various other health conditions.
Understanding IgG4 deficiency aids in diagnosing and managing associated symptoms and infections.