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Clinical relevance of food-specific IgG4 antibodies
1Midlands Asthma and Allergy Research Association, Derby, United Kingdom.
Abstract:
Although milk-specific IgG4 is frequently detectable in sera of apparently healthy individuals, the presence of alpha-casein (AC IgG4-specific) in high concentration (i.e. greater than 9.98 micrograms/ml) appears to be diagnostic of milk intolerance causing eczema in adults. The detection of egg-specific IgG4, on the other hand, has no similar diagnostic potential in egg-intolerant cases.