Related Experiment Video
Updated: Nov 16, 2025
06:14
In Vivo Protocol of Controlled Subconcussive Head Impacts for the Validation of Field Study Data
Published on: April 18, 2019
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Chronic traumatic encephalopathy
J Hugon1, C Hourregue1, E Cognat1
1Centre de neurologie cognitive, AP-HP, Hôpital Lariboisière FW, Université de Paris et INSERM U1144, 75010 Paris, France.
Neuro-Chirurgie
|February 23, 2021
Summary
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease from repeated head trauma. Prevention through strict medical protocols for athletes and veterans is crucial to mitigate risks associated with traumatic brain injury (TBI).
Area of Science:
- Neurology
- Neuroscience
- Sports Medicine
Background:
- Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease.
- It is strongly linked to repetitive traumatic brain injuries (TBIs).
- CTE is prevalent in athletes (boxers, football players) and military veterans.
Purpose of the Study:
- To review the neuropathological, clinical, and imaging findings in CTE.
- To discuss the diagnostic challenges and emphasize prevention strategies.
Main Methods:
- Review of neuropathological hallmarks: phosphorylated tau, TDP43, Aβ, and α-synuclein.
- Analysis of clinical presentations: behavioral, cognitive, and mixed variants.
- Examination of neuroimaging findings: MRI (atrophy, diffusion tensor imaging) and PET tau scans.
Main Results:
- Neuropathology shows tau accumulations in cerebral sulci and other protein deposits.
- Clinical variants manifest as behavioral changes, cognitive decline, or a mix.
- Imaging reveals diffuse atrophy, axonal abnormalities, and elevated tau PET SUVR in CTE patients.
Conclusions:
- CTE is a distinct neurodegenerative disease associated with TBI.
- Prevention, particularly in sports and military settings, is paramount.
- Strict medical guidance regarding return-to-play after concussion is essential.
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