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Tapentadol and Sleepwalking: A Case Report.

Elena You Jung Ko1, Michael W Tupper2,3

  • 1Department of Pharmacy, 22442Atrium Health's Carolinas Medical Center, Charlotte, NC, USA.

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|February 24, 2021
PubMed
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This case report details sleepwalking in a patient taking tapentadol ER. Exceeding recommended doses of this pain medication may cause sleepwalking due to its effects on the central nervous system.

Keywords:
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Area of Science:

  • Pharmacology
  • Neurology
  • Sleep Medicine

Background:

  • Tapentadol extended-release (ER) is prescribed for moderate to severe pain.
  • Dosage guidelines are established to ensure efficacy and minimize adverse events.

Observation:

  • A 39-year-old female experienced sleepwalking episodes.
  • These episodes correlated with an increase in tapentadol ER dosage above recommended limits.

Findings:

  • Tapentadol ER's mechanism, involving norepinephrine reuptake inhibition, may contribute to central nervous system alterations.
  • Higher dosages and potential drug interactions were identified as likely factors in the patient's sleepwalking.

Implications:

  • Adherence to recommended tapentadol ER dosage is crucial.
  • Close monitoring for adverse effects is essential when exceeding standard dosages for pain management.