ESTIMATION OF IMMUNOLOGICAL AND BIOCHEMICAL PARAMETERS IN HEPATITIS B POSITIVE PATIENTS

Area of Science:

• Immunology
• Hepatology
• Virology

Background:

• Hepatitis B virus (HBV) infection can alter immunological responses, potentially serving as diagnostic and prognostic markers.
• Understanding these immune changes is crucial for managing HBV infection.

Purpose of the Study:

• To measure and correlate serum levels of interleukin-2 (IL-2), C-reactive protein (CRP), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), and HBV antigens/antibodies in HBV patients and healthy controls.

Main Methods:

• The study included 26 HBsAg-seropositive HBV patients and 26 HBsAg-seronegative healthy controls.
• Biochemical liver markers (ALT, AST) were assessed using routine methods.
• Hepatitis B antigens and antibodies were determined by immunochromatography, and IL-2 and CRP levels were measured using ELISA.

Main Results:

• HBV patients exhibited significantly elevated AST and ALT levels compared to controls.
• Serum IL-2 levels were lower, and CRP levels were higher in HBV patients than in controls, though not statistically significant.
• A significant correlation was observed between IL-2 and CRP levels in HBV-infected individuals.

Conclusions:

• Deranged ALT and AST values are significantly associated with HBV infection.
• These liver enzymes may serve as potential tools for diagnosing HBV infection and monitoring disease progression.