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Updated: Nov 16, 2025

Differential Scanning Calorimetry — A Method for Assessing the Thermal Stability and Conformation of Protein Antigen
Published on: March 4, 2017
Analysis of vaccine loss due to temperature change
Flávia Dos Santos Patine1, Luciano Garcia Lourenção2, Anneliese Domingues Wysocki3
1Faculdade de Medicina de São José do Rio Preto. São José do Rio Preto, São Paulo, Brazil.
Objectives:
to analyze vaccine losses in a Health Region in the Northwest of São Paulo.
Methods:
retrospective cross-sectional study with secondary data obtained from Temperature Change Notification Forms used by the Epidemiological Surveillance Group XXIX of São José do Rio Preto between 2010 and 2017. Descriptive and inferential analysis were performed using multiple linear regression and significance level of 95%.
Results:
in total, 341 notifications of temperature changes were analyzed, of which 70.1% were caused by structural reasons, 57.8% in industrial refrigerators and 91.2% in primary care services. Of the doses that suffered a change in temperature, 41.4% were lost and 58.6% were administered to the population. The highest percentage of lost doses compared to those applied occurred in smaller municipalities, although they reported less.
Conclusions:
nursing workers who work in vaccination rooms should make efforts to prevent temperature changes and avoid losses and higher public expenses.
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Assessing Body Temperature - Axilla
Step 1: Perform hand hygiene and put on clean gloves to maintain infection control and prevent cross-contamination.
Step 2: Prepare the patient by explaining the procedure to ensure understanding and cooperation. Ensure privacy, expose the axilla, and inform the patient that minimal movement is crucial for an accurate reading.
Step 3: Adjust the patient’s clothing to expose only the axilla. It minimizes...

