Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Exploring the prognostic implications of programmed death-ligand 1 expression in canine nodal lymphoma: Insights from surface membrane expression, transcript amount and plasmatic levels.

Research in veterinary science·2026

Same author

In vitro compatibility of type-B feline blood with canine blood of different DEA 1 phenotypes and with type-A feline blood.

Veterinary journal (London, England : 1997)·2026

Same author

A Small-Molecule Drug Conjugate Targeting FAP Exhibits Potent Activity in Dogs with Spontaneous Tumors.

Journal of medicinal chemistry·2026

Same author

Look Trout in the Eye: Corneal Biomarkers of Ammonia Stress in Recirculating Aquaculture Systems Treated with TiO<sub>2</sub> Photoelectrocatalysis.

Veterinary sciences·2026

Same author

Radiographic patterns and lesion associations in feline pelvic trauma.

Journal of feline medicine and surgery·2026

Same author

Fluorescence changes at flow cytometric analysis of samples from sentinel lymph nodes excised with indocyanine green and methylene blue guided mapping techniques.

Frontiers in veterinary science·2026

Search research articles

Related Experiment Video

Updated: Nov 16, 2025

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

Prostatic leiomyosarcoma in a dog treated using a multimodal approach.

Marco Trovatelli¹, Jessica Bassi², Chiara Giudice¹

¹Department of Veterinary Medicine, Università degli Studi di Milano, Lodi, Italy.

Journal of Veterinary Internal Medicine

|February 24, 2021

Summary

This study reports the first successful treatment of prostatic leiomyosarcoma in a dog. A combination of surgery and chemotherapy led to a 15-month recurrence-free outcome for this rare canine tumor.

Keywords:

CT dog metronomic chemotherapy neoplasia prostate

More Related Videos

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Published on: October 24, 2016

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Related Experiment Videos

Last Updated: Nov 16, 2025

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Published on: October 24, 2016

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Area of Science:

Veterinary Oncology
Comparative Pathology

Background:

Prostatic leiomyosarcoma is a rare and aggressive tumor in male dogs, with limited documented cases and no established treatment protocols.
Early diagnosis and intervention are crucial for managing canine prostate cancer.

Observation:

A 12-year-old German Wirehaired Pointer presented with obstructive urinary and defecatory symptoms due to a large prostatic mass.
Computed tomography (CT) revealed a significant pelvic canal obliteration caused by the expansile prostatic tumor.

Findings:

Histopathology and immunohistochemistry confirmed the diagnosis of prostatic leiomyosarcoma.
Surgical resection (partial subcapsular prostatectomy) followed by metronomic cyclophosphamide and NSAIDs resulted in no recurrence or metastasis at 15 months post-treatment.

Implications:

This case highlights the potential efficacy of a multimodal treatment approach for canine prostatic leiomyosarcoma.
Successful management offers hope for improved outcomes in dogs diagnosed with this uncommon malignancy.
Further research into optimal treatment strategies for prostatic leiomyosarcoma in dogs is warranted.