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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
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IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
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Related Experiment Video

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Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
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Trace elements in patients with aortic valve sclerosis.

Hataw Al-Taesh1, Abuzer Çelekli2, Murat Sucu3

  • 1Department of Biochemistry Science and Technology, Institute of Natural and Applied Sciences, Faculty of Arts and Science, Gaziantep University, Gaziantep, Turkey.

Therapeutic Advances in Cardiovascular Disease
|February 25, 2021
PubMed
Summary

Aortic valve sclerosis (AVSc) is linked to trace element imbalances. Patients with AVSc showed significantly lower serum zinc levels compared to healthy individuals, suggesting zinc

Keywords:
aortic valve sclerosiscopperironseleniumzinc

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Area of Science:

  • Cardiology
  • Biochemistry
  • Trace Element Metabolism

Background:

  • Aortic valve sclerosis (AVSc) involves aortic valve thickening and calcification without outflow obstruction.
  • AVSc is associated with an imbalance in essential trace elements.

Purpose of the Study:

  • To investigate the relationship between AVSc and serum levels of iron (Fe), zinc (Zn), selenium (Se), and copper (Cu).
  • To explore the clinical significance of these trace elements as potential biomarkers for AVSc.
  • To clarify the pathophysiological role of these elements in AVSc development.

Main Methods:

  • A study involving 40 AVSc patients and a gender-matched healthy control group.
  • Echocardiography was used for AVSc diagnosis.
  • Serum concentrations of Zn and Cu were measured by atomic absorption spectroscopy; Se by ICP-MS; Fe by Beckman Coulter instrument.

Main Results:

  • AVSc patients exhibited significantly lower serum zinc (Zn) levels compared to controls (p < 0.01).
  • No significant differences were found in serum iron (Fe), selenium (Se), or copper (Cu) levels between groups (p > 0.05).
  • AVSc patients had higher prevalence of obesity, hypertension, and diabetes.

Conclusions:

  • Patients with AVSc demonstrate a trace element imbalance, notably lower serum zinc.
  • Serum zinc may serve as a potential biomarker for AVSc.
  • Obesity, hypertension, and diabetes are prevalent in AVSc patients, indicating complex multifactorial etiology.