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[Application of double plasma molecular adsorption system in children with acute liver failure]

Jie He1, Xin-Ping Zhang1, Xiong Zhou1

  • 1Intensive Care Unit, Hunan Children's Hospital, Changsha 410007, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|February 25, 2021
PubMed

Insights

The double plasma molecular absorption system (DPMAS) is a safe and effective treatment for pediatric acute liver failure (PALF), reducing ICU stay and improving key markers. It offers a viable alternative to traditional plasma exchange therapy.

Area of Science:

  • Hepatology
  • Pediatric Critical Care
  • Biomedical Engineering

Background:

  • Pediatric acute liver failure (PALF) presents significant management challenges.
  • Artificial liver support therapies are crucial for improving outcomes in PALF patients.

Purpose of the Study:

  • To evaluate the efficacy and safety of the double plasma molecular absorption system (DPMAS) for treating PALF.
  • To compare DPMAS with traditional plasma exchange (PE) in pediatric patients.

Main Methods:

  • A prospective study involving 36 PALF patients, randomly assigned to either PE or DPMAS groups (n=18 each).
  • Comparison of clinical indices, laboratory markers (pre- and post-treatment), and adverse events between the two groups.
  • Data collected from Hunan Children's Hospital between March 2018 and June 2020.

Main Results:

  • The DPMAS group showed a reduced need for artificial liver support and shorter ICU stays compared to the PE group (P < 0.05).
  • Both groups demonstrated reductions in total bilirubin, IL-6, and TNF-α, with greater reductions in the DPMAS group (P < 0.05).
  • No significant differences were observed in 12-week survival rates or overall adverse event incidence between the groups.

Conclusions:

  • DPMAS is a safe and effective treatment modality for PALF.
  • DPMAS can be considered a valuable alternative to conventional artificial liver support therapies in pediatric patients.
  • Further research may explore long-term outcomes and specific indications for DPMAS in PALF.
Abstract

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