Related Experiment Video

Updated: Nov 16, 2025

Utilizing a Cranial Window to Visualize the Middle Cerebral Artery During Endothelin-1 Induced Middle Cerebral Artery Occlusion
07:43

Utilizing a Cranial Window to Visualize the Middle Cerebral Artery During Endothelin-1 Induced Middle Cerebral Artery Occlusion

Published on: February 22, 2013

15.2K

Association between Clinical Characteristics and Laboratory Findings with Outcome of Hospitalized COVID-19 Patients:

Sahar Sobhani1, Reihaneh Aryan2, Elham Kalantari3

  • 1Department of Nursing and Midwifery, Faculty of Nursing, Gonabad University of Medical Sciences, Gonabad, Iran.

Interdisciplinary Perspectives on Infectious Diseases
|February 25, 2021
PubMed

Insights

Clinical and laboratory findings in COVID-19 patients predict outcomes. Factors like male sex, age, and elevated inflammatory markers (WBC, CRP) are linked to mortality and ICU admission, aiding in risk stratification.

Area of Science:

  • Infectious Diseases
  • Clinical Medicine
  • Epidemiology

Background:

  • Coronavirus disease 2019 (COVID-19) emerged in late 2019 and rapidly became a global pandemic.
  • Understanding clinical and laboratory predictors of COVID-19 outcomes is crucial for patient management and early diagnosis.
  • Retrospective analysis of hospitalized patients can provide valuable insights into disease progression and mortality factors.

Purpose of the Study:

  • To evaluate clinical characteristics and laboratory findings in hospitalized COVID-19 patients.
  • To identify factors associated with mortality, hospitalization duration, and intensive care unit (ICU) admission.
  • To explore the potential of these features in risk stratification and developing predictive tools for severe COVID-19 prognosis.

Main Methods:

  • Retrospective analysis of medical records from 397 hospitalized COVID-19 patients.
  • Data collected between February and May 2020 at Imam Reza Hospital, northeast Iran.
  • Comparison of clinical and laboratory features between survivors and non-survivors, and correlation analysis with hospitalization and ICU admission.

Main Results:

  • Male sex, older age, longer hospitalization, and ICU admission were significantly associated with higher mortality.
  • Headache correlated with survival and shorter hospital stays, while chest pain was linked to longer stays.
  • Decreased consciousness and dyspnea were more frequent in non-survivors. Elevated white blood cell (WBC), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were significantly higher in non-survivors and predicted ICU admission.

Conclusions:

  • Clinical features like chest pain, decreased consciousness, and dyspnea, along with laboratory markers (WBC, CRP), are potent predictors of severe COVID-19 prognosis.
  • These findings can assist clinicians in risk stratifying patients and developing predictive models for better management.
  • Early identification of high-risk patients through clinical and laboratory assessment is vital for improving COVID-19 outcomes.

More Related Videos

Identification and Isolation of Slow-Dividing Cells in Human Glioblastoma Using Carboxy Fluorescein Succinimidyl Ester CFSE11:54

Identification and Isolation of Slow-Dividing Cells in Human Glioblastoma Using Carboxy Fluorescein Succinimidyl Ester CFSE

Published on: April 29, 2012

14.3K
Protocol for Three-dimensional Confocal Morphometric Analysis of Astrocytes09:13

Protocol for Three-dimensional Confocal Morphometric Analysis of Astrocytes

Published on: December 11, 2015

9.2K

Related Concept Videos

Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
143
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
146
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
99
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.5K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
220
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
76