Related Experiment Video
Updated: Nov 16, 2025

05:27
Author Spotlight: Optimizing Scorpion Venom Extraction for Antivenom Production
Published on: October 6, 2023
3.7K
Scorpion Stings and Antivenom Use in Arizona
Stephen A Klotz1, Sarah Yates1, Shannon L Smith1
1Division of Infectious Diseases, Department of Medicine.
The American Journal of Medicine
|February 25, 2021
Summary
Arizona bark scorpion stings can cause severe symptoms. Antivenom effectively treats these stings, with rapid symptom resolution and no adverse reactions. Broader antivenom availability is recommended.
Area of Science:
- Toxicology
- Emergency Medicine
- Dermatology
Background:
- Arizona's desert environment is home to the venomous bark scorpion (Centruroides sculpturatus).
- Bark scorpion venom can lead to significant neuromotor disturbances.
- An effective antivenom for C. sculpturatus envenomation is available.
Purpose of the Study:
- To analyze scorpion sting calls in Arizona.
- To evaluate the clinical presentation and treatment of C. sculpturatus stings.
- To assess the efficacy and safety of antivenom for C. sculpturatus envenomation.
Main Methods:
- Analysis of 4398 scorpion sting calls to the Arizona Poison and Drug Information Center (APDIC) from 2017-2019.
- Clinical data collection from 593 patients treated at healthcare facilities.
- Review of antivenom administration and patient outcomes.
Main Results:
- Pain and numbness were the most common initial complaints.
- Neuromotor signs included nystagmus, hypersalivation, and fasciculations.
- Antivenom was administered to 145 patients, primarily children, with 54.5% meeting recommended use criteria.
Conclusions:
- Antivenom treatment led to rapid symptom resolution.
- No immediate or delayed hypersensitivity reactions were observed with antivenom.
- Expanded antivenom availability is recommended in high-risk areas.
Keywords:
AntivenomBark scorpionCentruroides sculpturatusFasciculationsHypersalivationRotary nystagmusScorpion stingsMore Related Videos
Related Concept Videos
Anticholinesterase Agents: Poisoning and Treatment
1.3K
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
1.3K
Allergic Reactions
30.0K
Overview
30.0K
Prevention of Further Absorption of Poison
1.0K
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.0K
Antidotes
876
Antidotes are medicinal substances used to counteract the harmful effects of toxins or drugs in the body. They function in various ways, each uniquely designed to combat specific toxic compounds.
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
876
Cross-reactivity
32.1K
Overview
32.1K
Allergic Drug Reactions
1.2K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.2K

