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Intravascular contrast media: effect of dose on renal function
D L Miller1, R Chang, W T Wells
1Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892.
Radiology
|June 1, 1988
Summary
This study found no consistent clinical effect on renal function from increasing doses of contrast material in adequately hydrated, low-risk patients. Contrast material dose did not significantly alter kidney function in the examined patient group.
Area of Science:
- Radiology
- Nephrology
Background:
- Contrast material administration is common in medical imaging.
- Assessing the impact of contrast material dose on renal function is crucial for patient safety.
Purpose of the Study:
- To prospectively evaluate the effect of varying contrast material doses on clinically evident changes in renal function.
- To determine if contrast material dose impacts renal function in adequately hydrated, low-risk patients.
Main Methods:
- Prospective study of 200 examinations involving intravenous or intraarterial contrast material.
- Measurement of blood urea nitrogen and serum creatinine before and after contrast administration.
- Analysis of data considering ionic and nonionic contrast agents and total dose administered.
Main Results:
- No consistent clinical effect on renal function was observed with increasing contrast material dose.
- This finding held true regardless of whether ionic or nonionic agents were used.
- No relationship was found between total dose and patient age or dose adjustments for pre-existing renal impairment.
Conclusions:
- In adequately hydrated, low-risk patients with normal initial renal function, increasing contrast material dose within the studied range does not appear to cause consistent clinical changes in renal function.
- The type of contrast agent (ionic vs. nonionic) did not alter this outcome.
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