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Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
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Chemerin in inflammatory diseases.

Xin Su1, Ye Cheng1, Guoming Zhang1

  • 1Department of Cardiology, the Xiamen Cardiovascular Hospital of Xiamen University, Xiamen, Fujian, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|February 25, 2021
PubMed
Summary
This summary is machine-generated.

Chemerin, a pro-inflammatory adipokine, is elevated in obesity and inflammation. Understanding its role in diseases could lead to new treatments for inflammatory conditions and tumors.

Keywords:
AdipokineChemerinInflammatory diseaseMetabolismTumor

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Area of Science:

  • Biochemistry
  • Immunology
  • Endocrinology

Background:

  • Obesity is linked to health issues, with dysfunctional adipocytes overproducing pro-inflammatory adipokines like chemerin.
  • Chemerin regulates adipocyte differentiation, immunity, and inflammation via the ChemR23 receptor.

Purpose of the Study:

  • To review current knowledge on chemerin's role in modulating inflammatory diseases.
  • To explore the biochemical and mechanistic basis of chemerin's function in various pathologies.

Main Methods:

  • Literature review of studies on chemerin's physiological and pathophysiological roles.
  • Analysis of chemerin's involvement in inflammatory processes and disease biomarkers.

Main Results:

  • Elevated serum chemerin is observed in inflammatory diseases and as a biomarker for tumors.
  • Chemerin's chemoattractant properties and role in early inflammation are highlighted.

Conclusions:

  • Elucidating chemerin's mechanisms can aid in developing novel therapeutic strategies.
  • Chemerin is a key regulator in diverse inflammatory diseases and potentially in oncology.