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LV non-compaction in patients with coarctation of the aorta: prevalence and effects on cardiac function

Preeti Choudhary1,2, Wendy Strugnell3, Rajesh Puranik1,2

  • 1Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia.

Cardiology in the Young
|February 26, 2021
PubMed

Insights

Left ventricular non-compaction is found in 8.2% of patients after coarctation of the aorta repair. This condition is linked to larger left ventricular volumes but not reduced ejection fraction.

Area of Science:

  • Cardiology
  • Congenital Heart Disease
  • Cardiac Imaging

Background:

  • Left ventricular non-compaction (LVNC) is linked to heart failure, arrhythmias, and sudden death.
  • The prevalence and clinical impact of LVNC in coarctation of the aorta (CoA) patients are not well understood.
  • Obstructive left heart disease is common in LVNC patients.

Purpose of the Study:

  • To determine the prevalence of LVNC in patients with repaired CoA.
  • To assess the effect of LVNC on left ventricular size and systolic function in these patients.

Main Methods:

  • Cardiac magnetic resonance imaging (CMR) was used for clinical follow-up in 268 patients with repaired CoA.
  • LVNC was defined by a non-compacted:compacted ratio >2.3 in the worst affected segment.
  • Clinical data was correlated with ventricular volumes and function.

Main Results:

  • LVNC was present in 8.2% of patients with repaired CoA.
  • Patients with LVNC had significantly higher left ventricular end-diastolic and stroke volumes.
  • No significant differences in ventricular mass or ejection fraction were observed between groups.

Conclusions:

  • LVNC is relatively common in patients with repaired coarctation of the aorta.
  • LVNC correlates with increased left ventricular end-diastolic volumes in this population.
Abstract

Keywords:
Coarctation of aortaheart failureleft ventricular non-compaction

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