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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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How Do We Move Type 1 Diabetes Immunotherapies Forward During the Current COVID-19 Pandemic?

Michael J Haller1, Laura M Jacobsen2, Amanda L Posgai3

  • 1Department of Pediatrics, University of Florida Diabetes Institute, College of Medicine, Gainesville, FL hallemj@peds.ufl.edu.

Diabetes
|February 26, 2021
PubMed

Insights

Type 1 diabetes immunotherapy trials were paused due to COVID-19. This perspective argues for carefully resuming trials, prioritizing patient safety and mitigating SARS-CoV-2 infection risks.

Area of Science:

  • Immunology
  • Endocrinology
  • Infectious Diseases

Background:

  • The COVID-19 pandemic caused widespread suspension of type 1 diabetes immunotherapy trials.
  • While diabetes is a risk factor for severe COVID-19 in adults, children and adolescents with type 1 diabetes show no increased risk.
  • Resuming clinical trials is crucial for advancing autoimmune disease research.

Purpose of the Study:

  • To advocate for the carefully staged resumption of type 1 diabetes immunotherapy trials.
  • To provide recommendations for mitigating SARS-CoV-2 infection risks in trial participants.
  • To ensure patient safety while advancing critical research during the ongoing pandemic.

Main Methods:

  • Reviewing experiences from oncology and rheumatology trials that continued or resumed during the pandemic.
  • Analyzing the risks and benefits of resuming type 1 diabetes immunotherapy trials.
  • Developing a framework for staged trial resumption and risk mitigation strategies.

Main Results:

  • Compelling arguments exist for resuming certain type 1 diabetes immunotherapy trials.
  • Lessons learned from other fields can inform safe trial resumption.
  • Specific recommendations can balance research needs with infection control.

Conclusions:

  • Staged resumption of type 1 diabetes immunotherapy trials is feasible and necessary.
  • Implementing robust safety protocols can protect participants from SARS-CoV-2.
  • Moving forward with research benefits patients with autoimmune diseases.

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