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[HIV-associated thrombocytopenia].

J Jost1, M G Täuber, R Lüthy

  • 1Department für Innere Medizin, Medizinische Poliklinik, Universitätsspital Zürich.

Schweizerische Medizinische Wochenschrift
|February 13, 1988
PubMed
Summary
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HIV-associated thrombocytopenia is more severe in intravenous drug users than in homosexual men. Therapy should be reserved for severely symptomatic patients, as serious complications are rare and corticosteroid effects on HIV progression are unknown.

Area of Science:

  • Hematology
  • Virology
  • Immunology

Context:

  • Thrombocytopenia is a common complication in human immunodeficiency virus (HIV) infection.
  • Incidence varies between risk groups: 3% in homosexual men, 9% in intravenous drug users.
  • Prospective study of 42 HIV-positive thrombocytopenic patients.

Purpose:

  • To investigate the clinical significance of thrombocytopenia in HIV-infected individuals.
  • To compare severity and bleeding symptoms between different risk groups.
  • To evaluate treatment outcomes for symptomatic thrombocytopenia.

Summary:

  • Thrombocytopenia was more severe in intravenous drug users (52% <10,000/mm3) than homosexual men (9%).
  • Bleeding symptoms (skin/mucosal) were more frequent in drug users (45%) vs. homosexual men (18%).

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  • Life-threatening bleeding did not occur; prednisone offered temporary benefit in symptomatic cases.

    • Impact:

    • HIV-associated thrombocytopenia rarely causes severe complications.
    • Treatment should be reserved for severely symptomatic patients.
    • The impact of corticosteroids on HIV progression remains unknown, warranting cautious use.