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A Technical Guide for Performing Spectroscopic Measurements on Metal-Organic Frameworks
Published on: April 28, 2023
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The recent progress on metal-organic frameworks for phototherapy.
Qiyao Zheng1, Xiangmei Liu2, Yufeng Zheng3
1School of Materials Science & Engineering, The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China. shuilinwu@tju.edu.cn.
Chemical Society Reviews
|February 26, 2021
Summary
Metal-organic frameworks (MOFs) offer a promising antibiotic-free phototherapy approach for diseases like cancer. These versatile materials can be engineered for photodynamic therapy (PDT) or photothermal therapy (PTT), enhancing treatment efficacy.
Area of Science:
- Materials Science
- Biomedical Engineering
- Nanotechnology
Background:
- Antibiotic therapies face limitations, including drug resistance and adverse effects.
- Phototherapy presents an emerging antibiotic-free alternative for treating diseases.
- Photodynamic therapy (PDT) and photothermal therapy (PTT) utilize light-activated agents to eliminate targeted cells.
Purpose of the Study:
- To review the principles of phototherapy.
- To summarize recent advancements in metal-organic frameworks (MOFs) for PDT, PTT, and synergistic therapies.
- To explore MOF construction, modification, and applications in phototherapy.
Main Methods:
- Literature review of phototherapy principles.
- Comprehensive summary of MOF-based phototherapy strategies.
- Analysis of MOF design for enhanced photodynamic and photothermal capabilities.
Main Results:
- MOFs show significant promise as photo-responsive materials due to their tunable structure and porosity.
- MOFs can be designed for intrinsic PDT or PTT, or act as carriers for therapeutic agents.
- MOFs facilitate combined therapies and targeting, improving phototherapy efficiency.
Conclusions:
- MOFs are highly adaptable materials for advanced phototherapy applications.
- Rational design of MOFs is crucial for optimizing photodynamic and photothermal effects.
- Further development of MOFs in phototherapy could accelerate clinical translation.
