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Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
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Hindering triple negative breast cancer progression by targeting endogenous interleukin-30 requires IFNγ signaling
Carlo Sorrentino1,2, Stefania Livia Ciummo1,2, Luigi D'Antonio1,2
1Department of Medicine and Sciences of Aging, "G. d'Annunzio" University, Chieti, Italy.
Clinical and Translational Medicine
|February 26, 2021
Abstract:
IL30mRNA expression is associated with the TNBC subtype. IL30 boosts proliferation and migration of TNBC cells and reshapes their immunity gene expression profile. The lack of endogenous IL30 hinders TNBC growth and progression and prolongs host survival. TNBC growth inhibition, due to the lack of endogenous IL30, requires INFγ production by T and NK cells.
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