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Related Concept Videos

Coagulation01:06

Coagulation

614
Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
614
Coagulation01:09

Coagulation

8.7K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
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How to use a coagulation screen.

Sarah Kapur1, Mark Gilmore2, Christine Macartney3

  • 1Children's Haematology Unit, Royal Belfast Hospital for Sick Children, Belfast, UK sarahkapur@doctors.org.uk.

Archives of Disease in Childhood. Education and Practice Edition
|February 27, 2021
PubMed
Summary
This summary is machine-generated.

Interpreting a coagulation screen in children requires careful consideration of age-specific normal ranges and clinical context. Understanding preanalytical variables and test limitations is crucial for accurate diagnosis of bleeding disorders.

Keywords:
neonatologyphysiology

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Area of Science:

  • Pediatric Hematology
  • Clinical Pathology
  • Hemostasis and Thrombosis

Background:

  • Coagulation screening is vital for diagnosing pediatric bleeding disorders.
  • Interpreting these tests in children presents unique challenges due to evolving hemostasis.
  • Age-specific normal ranges and clinical correlation are essential for accurate assessment.

Purpose of the Study:

  • To highlight the complexities in interpreting pediatric coagulation screens.
  • To emphasize the importance of considering age-related variations and clinical context.
  • To discuss the impact of preanalytical variables on test results.

Main Methods:

  • Review of current literature on pediatric coagulation testing.
  • Analysis of factors influencing coagulation screen interpretation.
  • Discussion of common pitfalls and limitations.

Main Results:

  • Coagulation screen interpretation in children is age-dependent.
  • Preanalytical factors significantly impact test accuracy.
  • Abnormal results may indicate bleeding disorders but can also stem from sampling errors.

Conclusions:

  • Accurate interpretation of pediatric coagulation screens necessitates awareness of age-specific norms and clinical presentation.
  • Meticulous attention to preanalytical conditions is paramount for reliable results.
  • Clinicians must be aware of the limitations of coagulation screens in diagnosing bleeding disorders.