Ultra-processed food targets bone quality via endochondral ossification

Area of Science:

• Nutritional Science
• Skeletal Biology
• Developmental Biology

Background:

• Ultra-processed foods (UPFs) are linked to negative health outcomes.
• The impact of UPFs on skeletal development remains unexplored.

Purpose of the Study:

• To investigate the effects of UPFs on skeletal development in young rats.
• To identify specific skeletal pathologies induced by UPF consumption.

Main Methods:

• Young rats were fed a diet rich in fat and sugar (ultra-processed).
• Skeletal development, bone mineral density, and structural parameters were assessed.
• RNA sequencing analyzed gene expression in growth plates.

Main Results:

• UPF consumption led to growth retardation and tibial growth plate lesions.
• Significant decreases in bone mineral density and deterioration of bone structure (cortical and trabecular) were observed.
• RNA sequencing revealed impaired extracellular matrix dynamics, proliferation, differentiation, and mineralization.

Conclusions:

• Ultra-processed foods severely impact growing skeletons, extending beyond known metabolic effects.
• Bone is identified as a novel target for understanding the health consequences of modern diets.
• This study provides the first evidence of UPFs causing skeletal pathologies in young animals.