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The impact of thrombo-inflammation on the cerebral microcirculation

Junaid Ansari1, Felicity N E Gavins2

  • 1Department of Neurology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, USA.

Microcirculation (New York, N.Y. : 1994)
|February 27, 2021
PubMed

Insights

Neutrophils significantly impact cerebrovascular diseases through thrombo-inflammation. Understanding their dual role in inflammation and resolution is key for developing new stroke treatments targeting neuroprotection.

Area of Science:

  • Neuroscience
  • Immunology
  • Cardiovascular Medicine

Background:

  • Thrombo-inflammation, the interplay of thrombosis and inflammation, is a key factor in cerebrovascular diseases.
  • Chronic microcirculatory dysfunction from conditions like hypertension and diabetes underlies most cerebrovascular events.
  • Immune cells, particularly neutrophils, are central to neuroinflammation in the microcirculation.

Purpose of the Study:

  • To elucidate the pathophysiological role of neutrophils in stroke.
  • To review current pharmacotherapeutic strategies for cerebrovascular diseases.
  • To identify potential therapeutic targets for neuroprotection and inflammation mitigation.

Main Methods:

  • Review of existing literature on neutrophils, thrombo-inflammation, and stroke.
  • Analysis of the dual role of neutrophils in physiological versus pathological vascular states.
  • Discussion of ongoing drug discovery programs and therapeutic targets.

Main Results:

  • Neutrophils exhibit context-dependent roles, mediating both inflammatory and pro-resolution effects.
  • Their involvement is critical in the initiation and progression of neuroinflammatory responses.
  • Understanding neutrophil function offers avenues for therapeutic intervention in stroke.

Conclusions:

  • Targeting neutrophil function presents a promising strategy for treating cerebrovascular diseases.
  • Pharmacotherapies aimed at modulating neutrophil activity can enhance neuroprotection and promote resolution.
  • Further research into neutrophil-specific targets is crucial for effective stroke management.

Keywords:
inflammationneutrophilsstrokethrombosis

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