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Published on: September 15, 2017
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Epigenomic and transcriptomic analysis of chronic inflammatory diseases
Sabrina Ka Man Tam1, Danny Chi Yeu Leung2
1Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, SAR.
Genes & Genomics
|February 27, 2021
Summary
Epigenetic modifications are key to understanding chronic inflammatory diseases (CIDs). Single-cell genomics reveals immune cell-specific changes, offering new diagnostic and treatment insights for CIDs.
Area of Science:
- Immunology
- Genomics
- Epigenetics
Background:
- Chronic inflammatory diseases (CIDs) involve complex, persistent immune responses with unclear triggers.
- Epigenetic modifications regulate gene expression and immune responses, linking epigenomics and CIDs.
- Cell type heterogeneity complicates CID diagnosis and treatment.
Purpose of the Study:
- To review the current state of epigenomics research in CIDs.
- To highlight insights from single-cell transcriptomic and epigenomic studies.
- To explore the role of epigenetic changes in immune cell alterations and disease etiology.
Main Methods:
- Review of current literature on CIDs, epigenomics, and single-cell genomics.
- Analysis of epigenomic and transcriptomic data in the context of CIDs.
- Focus on cis-regulatory elements and immune cell-specific alterations.
Main Results:
- Epigenomic and transcriptomic dysregulation is associated with CID phenotypes.
- Epigenetic changes at cis-regulatory elements provide insights into immune cell alterations.
- Single-cell genomics addresses cell type heterogeneity challenges in CIDs.
Conclusions:
- Epigenomics offers critical insights into the mechanisms of CIDs.
- Single-cell studies are advancing our understanding of immune cell roles in CIDs.
- Targeting epigenetic modifications presents potential therapeutic strategies for CIDs.
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