Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.4K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.4K
Epigenetic Regulation01:46

Epigenetic Regulation

32.0K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
32.0K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

36.0K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.0K
What is Genetic Engineering?00:49

What is Genetic Engineering?

77.0K
Overview
77.0K
Human Genetics01:28

Human Genetics

1.1K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.1K
CRISPR01:59

CRISPR

54.7K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
54.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Angiogenesis in Pancreatic Cancer: Pre-Clinical and Clinical Studies.

Cancers·2019
Same author

Inflammatory cells infiltrate and angiogenesis in locally advanced and metastatic cholangiocarcinoma.

European journal of clinical investigation·2019
Same author

Microvascular density, macrophages, and mast cells in human clear cell renal carcinoma with and without bevacizumab treatment.

Urologic oncology·2019
Same author

Immunophenotypic characterization of telocyte-like cells in pterygium.

Molecular vision·2019
Same author

α-Methyl-prednisolone normalizes the PKC mediated brain angiogenesis in dystrophic mdx mice.

Brain research bulletin·2019
Same author

Mast Cells and Angiogenesis in Human Plasma Cell Malignancies.

International journal of molecular sciences·2019
Same journal

PFKFB2-Induced Glycolysis and Ferroptosis in Diabetic Nephropathy by HIF-1α.

Critical reviews in eukaryotic gene expression·2026
Same journal

LncRNA MANCR Acts as a ceRNA to Sponge MicroRNA-20a-5p and Upregulate GCNT4 to Suppress Angiogenesis in Colorectal Cancer.

Critical reviews in eukaryotic gene expression·2026
Same journal

Mechanistic Study of the Pink1/Parkin Signaling Pathway in Mitochondrial Dysfunction and Podocyte Injury.

Critical reviews in eukaryotic gene expression·2026
Same journal

Recent Advances in CRISPR-Cas Systems for Dengue Virus Detection.

Critical reviews in eukaryotic gene expression·2026
Same journal

A Lack of Association between Vitamin D Receptor Gene Polymorphisms with Colorectal Cancer: A Comprehensive Meta-Analysis and Power Assessment.

Critical reviews in eukaryotic gene expression·2026
Same journal

Use of Rituximab in Pediatric Nephrology: A Bibliometric and Visualization Analysis from 2003 to 2024.

Critical reviews in eukaryotic gene expression·2025
See all related articles

Related Experiment Video

Updated: Nov 16, 2025

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

23.8K

Epigenetics and Its Ethical Implications.

Domenico Ribatti1

  • 1Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Piazza Giulio Cesare, 11, Policlinico, 70124 Bari, Italy.

Critical Reviews in Eukaryotic Gene Expression
|February 27, 2021
PubMed
Summary
This summary is machine-generated.

Epigenetics involves gene expression changes without altering DNA sequence, impacting adaptation and disease. These reversible modifications can be inherited, potentially perpetuating advantages or disadvantages across generations.

More Related Videos

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

8.4K
Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

5.3K

Related Experiment Videos

Last Updated: Nov 16, 2025

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

23.8K
Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

8.4K
Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

5.3K

Area of Science:

  • Genetics and Molecular Biology
  • Developmental Biology

Background:

  • Epigenetics, coined by Conrad Waddington, studies gene-environment interactions.
  • Epigenetic mechanisms regulate gene activation without changing DNA structure.
  • These changes are rapid, reversible, and partly heritable.

Purpose of the Study:

  • To explore the fundamental mechanisms and implications of epigenetics.
  • To highlight the role of epigenetics in adaptation and disease pathogenesis.
  • To discuss the potential for epigenetic therapies and intergenerational effects.

Main Methods:

  • Conceptual review of epigenetic principles.
  • Analysis of molecular mechanisms underlying epigenetic modifications.
  • Examination of the role of epigenetics in health and disease.

Main Results:

  • Epigenetic modifications influence gene expression and organismal adaptation.
  • The epigenome allows individuals to adapt to environmental factors.
  • Epigenetics is implicated in diseases like cancer, obesity, and neurodegeneration.

Conclusions:

  • Epigenetic changes are crucial for adaptation and disease development.
  • The reversibility of epigenetic modifications offers therapeutic potential.
  • Inherited epigenetic factors can perpetuate societal inequalities across generations.