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Manufacture and Drug Delivery Applications of Silk Nanoparticles

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Published on: October 8, 2016

Therapeutic nanostructures and nanotoxicity.

Anupam Sarma¹, Ratnali Bania¹, Juti Rani Devi¹

¹Department of Pharmaceutics, Pratiksha Institute of Pharmaceutical Sciences, Guwahati, India.

Journal of Applied Toxicology : JAT

|February 28, 2021

Summary

Nanoparticle therapeutics offer promise but require thorough toxicity assessment. Understanding nanotoxicity mechanisms is crucial for safe nanomedicine development and regulatory approval.

Keywords:

carbon nanotubes dendrimer drug delivery nanocarrier nanoparticle nanosafety regulatory targeting

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Area of Science:

Nanomedicine
Toxicology
Biotechnology

Background:

Nanotechnology enables novel therapeutics like liposomes and polymeric nanoparticles for complex diseases.
Limited research exists on nanotherapeutic toxicity, hindering understanding of potential side effects.
Nanoparticles can distribute widely, interact with cells, and cause toxicity due to their physicochemical properties.

Purpose of the Study:

To review nanostructures used in therapeutic delivery systems.
To explore physicochemical characteristics linked to adverse biological effects.
To discuss toxicity evaluation models and regulatory challenges for nanotherapeutics.

Main Methods:

Literature review of nanostructures for drug delivery.
Analysis of physicochemical properties influencing nanotoxicity.
Examination of toxicity assessment models and regulatory considerations.

Main Results:

Nanoparticle properties (size, surface area, surface chemistry) significantly impact nanotoxicity.
Mechanisms of cellular interaction and injury by nanoparticles are key areas of concern.
Various toxicity evaluation models are employed, but standardization and regulatory frameworks are evolving.

Conclusions:

Comprehensive toxicity assessment is essential for nanotherapeutic development.
Further research into nanotoxicity mechanisms is vital for safe clinical translation.
Addressing environmental and regulatory hurdles is necessary for widespread nanomedicine adoption.