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A Structured Approach to Extubation in Mechanically Ventilated Rats

A Structured Approach to Extubation in Mechanically Ventilated Rats

Published on: July 18, 2025

Non-invasive high-frequency oscillatory ventilation in preterm infants after extubation: a randomized, controlled

Yan Li^1,2, Qiufen Wei², Dan Zhao²

¹Department of Neonatology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.

The Journal of International Medical Research

|March 1, 2021

Abstract

Objective:

To investigate the effectiveness and safety of non-invasive high-frequency oscillatory ventilation (NHFOV) in post-extubation preterm infants.

Methods:

This was a randomized, controlled trial. A total of 149 preterm infants aged between 25 to 34 weeks' gestational age with a birth weight of <1500 g who required invasive mechanical ventilation on admission were included. After extubation, they were randomized to the NHFOV group (n = 47), nasal intermittent positive pressure ventilation (NIPPV) group (n = 51), or nasal continuous positive airway pressure (NCPAP) group (n = 51). We compared the effectiveness and safety among these three groups.

Results:

A total of 139 preterm infants finally completed the study. The reintubation rate was significantly lower in the NHFOV group than in the other groups. The duration of non-invasive ventilation and the length of hospital stay in the NHFOV and NIPPV groups were significantly shorter than those in the NCPAP group. The incidence of bronchopulmonary dysplasia in the NHFOV and NIPPV groups was significantly lower than that in the NCPAP group. The NHFOV group had significantly less nasal injury than the NCPAP group.

Conclusion:

As post-extubation respiratory support in preterm infants, NHFOV has a lower reintubation rate compared with NCPAP and NIPPV, without increasing the rate of complications.

Keywords:

Preterm infant bronchopulmonary dysplasia invasive ventilation nasal continuous positive airway pressure non-invasive high-frequency oscillatory ventilation post-extubation

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