Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Nov 16, 2025

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice
08:59

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice

Published on: March 3, 2023

2.4K

Place Cells in Head-Fixed Mice Navigating a Floating Real-World Environment.

Mary Ann Go1, Jake Rogers1, Giuseppe P Gava1

  • 1Department of Bioengineering and Centre for Neurotechnology, Imperial College London, London, United Kingdom.

Frontiers in Cellular Neuroscience
|March 1, 2021
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Three-dimensional quantitative morphometric analysis (QMA) allows for reproducible and sensitive assessment of bone and joint in a preclinical mouse model of osteoarthritis.

JBMR plus·2026
Same author

Standardized Effect Measures Informing Next-Generation Strategies for Mechanical Stimulation in Cartilage Tissue Engineering.

Advanced healthcare materials·2026
Same author

Correction of connectivity induced by autocorrelation and filtering in resting state functional near-infrared spectroscopy data.

Journal of neuroscience methods·2026
Same author

Antibody-Mediated Delivery of BRM/BRG1 Protein Degraders Affords Strong Antitumor Efficacy in Multiple BRM-Dependent Non-Small Cell Lung Cancer Xenograft Models.

Journal of medicinal chemistry·2026
Same author

Ultra-wide-field, deep, adaptive two-photon microscopy for multi-scale neuronal imaging.

Light, science & applications·2026
Same author

Cueing motivation.

Nature reviews. Neuroscience·2026
Same journal

Brief mechanical pulses induce sustained intracellular L-lactate production in astrocytes.

Frontiers in cellular neuroscience·2026
Same journal

Effects of ethanol leaf extract of <i>Spondias mombin</i> on scopolamine-induced hippocampal neurodegeneration in adult male Wistar rats: evidence from behavioral, biochemical, histological, and immunohistochemical analyses.

Frontiers in cellular neuroscience·2026
Same journal

Ferroptosis in intracerebral hemorrhage: a bibliometric overview of mechanisms and future directions.

Frontiers in cellular neuroscience·2026
Same journal

<i>Scn2a</i>, encoding Na <sub><i>V</i></sub> 1.2 channel, contributes to tonotopic maturation of spike kinetics in developing mouse MNTB.

Frontiers in cellular neuroscience·2026
Same journal

From cellular heterogeneity to precision medicine: single-cell multi-omics in CNS disease research.

Frontiers in cellular neuroscience·2026
Same journal

Mesenchymal stromal/stem cells for neurological disorders in humans: an evidence-mapped clinical review.

Frontiers in cellular neuroscience·2026
See all related articles

This study introduces a novel real-world environment for head-fixed mice, enabling better study of hippocampal place cells and spatial memory. This system overcomes limitations of virtual reality, offering new insights into brain circuits.

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Memory Research

Background:

  • The hippocampal place cell system is crucial for understanding memory in rodents.
  • Previous studies in virtual reality showed impaired spatial coding in head-fixed animals.
  • A need exists for improved experimental systems to study spatial memory in head-fixed models.

Purpose of the Study:

  • To demonstrate the efficacy of a real-world environment system for head-fixed mice.
  • To investigate spatial coding and place cell activity in a novel experimental setup.
  • To validate a new platform for studying memory function and dysfunction.

Main Methods:

  • Head-fixed mice navigated a real-world environment on an air-floating track with proximal cues.
  • Hippocampal activity was imaged using the genetically encoded calcium indicator GCaMP6s.
Keywords:
behaviorcalcium imaginghippocampus (CA1)spatial memorytwo-photon

More Related Videos

Behavioral Training Procedures for Head-fixed Virtual Reality in Mice
06:27

Behavioral Training Procedures for Head-fixed Virtual Reality in Mice

Published on: September 6, 2024

1.7K
Two-photon Calcium Imaging in Mice Navigating a Virtual Reality Environment
08:12

Two-photon Calcium Imaging in Mice Navigating a Virtual Reality Environment

Published on: February 20, 2014

31.8K

Related Experiment Videos

Last Updated: Nov 16, 2025

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice
08:59

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice

Published on: March 3, 2023

2.4K
Behavioral Training Procedures for Head-fixed Virtual Reality in Mice
06:27

Behavioral Training Procedures for Head-fixed Virtual Reality in Mice

Published on: September 6, 2024

1.7K
Two-photon Calcium Imaging in Mice Navigating a Virtual Reality Environment
08:12

Two-photon Calcium Imaging in Mice Navigating a Virtual Reality Environment

Published on: February 20, 2014

31.8K
  • Place cell tuning, remapping, and spatial information rates were analyzed.

    • Main Results:

    • Consistent place tuning was observed in hippocampal cells, even without distal cues.
    • Place fields showed remapping when environments changed and over time.
    • Spatial information rates were comparable to freely moving mice, with low-dimensional subspace extraction.

    Conclusions:

    • The air-lifted real-world platform effectively supports place cell activity in head-fixed mice.
    • This system offers advantages over virtual reality for studying spatial memory.
    • The platform is a valuable tool for investigating brain circuits in memory and neurodegenerative disorders.