The Balance between Two Branches of RAS Can Protect from Severe COVID-19 Course

Area of Science:

• Pulmonary Medicine
• Molecular Biology
• Immunology

Background:

• COVID-19 pathogenesis involves complex physiological and molecular mechanisms.
• The renin-angiotensin system (RAS) and receptors of advanced glycation end products (RAGE) are crucial in lung physiology and pathology.
• Understanding these systems is vital for effective COVID-19 therapies.

Purpose of the Study:

• To detail the interaction between RAS and RAGE components in COVID-19.
• To review therapeutic strategies for correcting RAS dysfunction caused by SARS-CoV-2 binding to ACE2.
• To analyze data for developing complex treatments against severe COVID-19.

Main Methods:

• Literature review of theoretical, clinical, and experimental data.
• Analysis of the role of RAS and RAGE in COVID-19.
• Examination of therapeutic interventions targeting specific pathways.

Main Results:

• The interaction of RAS and RAGE contributes to lung injury in COVID-19, including ARDS and cytokine storm.
• SARS-CoV-2 binding to ACE2 disrupts normal RAS function.
• Potential therapies include MasR agonists, AT1R and NF-κB pathway blockers, and neuroprotective agents.

Conclusions:

• A multifaceted treatment approach is necessary to prevent severe COVID-19.
• Targeting RAS/RAGE pathways and utilizing neuroprotective compounds show promise.
• Further research into these mechanisms can guide clinical management of COVID-19.