Jove
Visualize
Contact Us

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.2K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.2K
Types of Receptors: Cell Surface Receptors01:28

Types of Receptors: Cell Surface Receptors

17.2K
Cell-surface receptors, also known as transmembrane receptors, are cell surface, membrane-anchored (integral) proteins that bind to external ligand molecules. This type of receptor spans the plasma membrane and performs signal transduction, converting an extracellular signal into an intracellular signal. Ligands that interact with cell-surface receptors do not have to enter the cell that they affect. Cell-surface receptors are also called cell-specific proteins or markers because they are...
17.2K
Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

104.9K
Overview
104.9K
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

2.1K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
2.1K
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

3.3K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
3.3K
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

12.5K
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
12.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Personalised treatment of patients with immune thrombotic thrombocytopenic purpura].

Terapevticheskii arkhiv·2025
Same author

Erratum to: Experimental Search for New Means of Pathogenetic Therapy COVID-19: Inhibitor of H2-Receptors Famotidine Increases the Effect of Oseltamivir on Survival and Immune Status of Mice Infected by A/PR/8/34 (H1N1).

Journal of evolutionary biochemistry and physiology·2022
Same author

Experimental Search for New Means of Pathogenetic Therapy COVID-19: Inhibitor of H2-Receptors Famotidine Increases the Effect of Oseltamivir on Survival and Immune Status of Mice Infected by A/PR/8/34 (H1N1).

Journal of evolutionary biochemistry and physiology·2022
Same author

Markers of Endothelial Cells in Normal and Pathological Conditions.

Biochemistry (Moscow) Supplement. Series A, Membrane and cell biology·2020
Same author

[Clinical observation of a patient with thrombotic thrombocytopenic purpura with renal and intestinal lesions].

Terapevticheskii arkhiv·2020
Same author

Effect of Bioactive Peptide Complex Isolated from Bovine Serum on Proliferation and Migration of Mesenchymal Stromal Cells In Vitro and Reparation of Bone Defects In Vivo.

Bulletin of experimental biology and medicine·2019
Same journal

Structural insights into function of ionotropic glutamate receptors.

Biochemistry (Moscow) Supplement. Series A, Membrane and cell biology·2026
Same journal

Physico-Chemical Mechanisms of the Functioning of Membrane-Active Proteins of Enveloped Viruses.

Biochemistry (Moscow) Supplement. Series A, Membrane and cell biology·2022
Same journal

The Mechanisms of Lipid Vesicle Fusion Inhibition by Extracts of Chaga and Buckthorn Leaves.

Biochemistry (Moscow) Supplement. Series A, Membrane and cell biology·2022
Same journal

Principles and Problems of Exosome Isolation from Biological Fluids.

Biochemistry (Moscow) Supplement. Series A, Membrane and cell biology·2022
Same journal

Liposomes as Adjuvants and Vaccine Delivery Systems.

Biochemistry (Moscow) Supplement. Series A, Membrane and cell biology·2022
Same journal

Structure and Functions of Gap Junctions and Their Constituent Connexins in the Mammalian CNS.

Biochemistry (Moscow) Supplement. Series A, Membrane and cell biology·2021
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Aug 4, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
05:23

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization

Published on: December 23, 2020

6.1K

SARS-CoV-2 Receptors and Their Involvement in Cell Infection.

P P Avdonin1, E Yu Rybakova1, S K Trufanov1

  • 1N.K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russia.

Biochemistry (Moscow) Supplement. Series A, Membrane and Cell Biology
|April 3, 2023
PubMed
Summary
This summary is machine-generated.

The COVID-19 pandemic spread widely due to SARS-CoV-2

Keywords:
ACE2ASGR1CD147CD209GRP78KREMEN1SARS-CoV-2cathepsin Lcoronavirusfurinheparan sulfateneuropilinreceptorstyrosine protein kinase AXL

More Related Videos

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

2.8K
High-throughput Confocal Imaging of Quantum Dot-Conjugated SARS-CoV-2 Spike Trimers to Track Binding and Endocytosis in HEK293T Cells
06:39

High-throughput Confocal Imaging of Quantum Dot-Conjugated SARS-CoV-2 Spike Trimers to Track Binding and Endocytosis in HEK293T Cells

Published on: April 21, 2022

3.1K

Related Experiment Videos

Last Updated: Aug 4, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
05:23

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization

Published on: December 23, 2020

6.1K
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

2.8K
High-throughput Confocal Imaging of Quantum Dot-Conjugated SARS-CoV-2 Spike Trimers to Track Binding and Endocytosis in HEK293T Cells
06:39

High-throughput Confocal Imaging of Quantum Dot-Conjugated SARS-CoV-2 Spike Trimers to Track Binding and Endocytosis in HEK293T Cells

Published on: April 21, 2022

3.1K

Area of Science:

  • Virology
  • Infectious Diseases
  • Molecular Biology

Background:

  • The SARS-CoV-2 virus caused a global pandemic, exceeding the impact of SARS-CoV and MERS-CoV.
  • Viral protein interactions with host cell receptors are key to infection spread.

Purpose of the Study:

  • To review known and novel host cell receptors utilized by SARS-CoV-2.
  • To understand the molecular basis for SARS-CoV-2's broader host cell interaction.

Main Methods:

  • Literature review of virology and molecular biology studies.
  • Comparative analysis of SARS-CoV, MERS-CoV, and SARS-CoV-2 protein sequences.
  • Identification of host cell receptor binding sites.

Main Results:

  • SARS-CoV-2 possesses unique protein interaction sites compared to SARS-CoV and MERS-CoV.
  • A broader range of host cell receptors are targeted by SARS-CoV-2.
  • Specific novel receptors for SARS-CoV-2 have been identified.

Conclusions:

  • The distinct protein features of SARS-CoV-2 contribute to its enhanced transmissibility.
  • Understanding these viral-host interactions is crucial for developing effective countermeasures against COVID-19.