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Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
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Coronary Artery Disease I: Introduction01:30

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Pseudogenes in Cardiovascular Disease.

Yanyan Qi1, Xi Wang2, Wenbo Li3

  • 1Department of Cardiology, Anesthesiology and Emergency Medicine, Henan Province People's Hospital and People's Hospital of Zhengzhou University, Zhengzhou, China.

Frontiers in Molecular Biosciences
|March 1, 2021
PubMed
Summary
This summary is machine-generated.

Pseudogenes, once dismissed as "junk," are now recognized as key players in cardiovascular disease development. Understanding their molecular roles offers new avenues for diagnosing and treating heart conditions.

Keywords:
cardiovascular diseasegene regulationmutationnon-coding geneprotein-codingpseudogenes

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiology

Background:

  • Cardiovascular diseases (CVDs) are a leading cause of mortality worldwide.
  • Emerging research highlights the involvement of pseudogenes in disease pathogenesis.
  • Pseudogenes are non-coding DNA sequences similar to protein-coding genes.

Purpose of the Study:

  • To review the current understanding of pseudogenes.
  • To explore the specific roles of pseudogenes in the development of cardiovascular diseases.
  • To discuss the potential of pseudogenes as biomarkers and therapeutic targets for CVDs.

Main Methods:

  • Literature review of recent studies on pseudogenes and cardiovascular diseases.
  • Analysis of pseudogene identification methods using sequencing and bioinformatics.
  • Synthesis of evidence linking pseudogene function to CVD pathogenesis.

Main Results:

  • Pseudogenes are increasingly identifiable due to advancements in technology.
  • Specific pseudogenes have been implicated in the molecular mechanisms underlying cardiovascular diseases.
  • Pseudogenes' high homology to parental genes presents identification challenges.

Conclusions:

  • Pseudogenes are significant contributors to cardiovascular disease.
  • Further research into pseudogenes can lead to novel diagnostic biomarkers.
  • Targeting pseudogenes may offer new therapeutic strategies for cardiovascular conditions.