Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developmental intestinal vascular responses to venous pressure elevation.

K D Crissinger1, P R Kvietys, D N Granger

  • 1Department of Physiology and Biophysics, Louisiana State University Medical Center, Shreveport 71130-3932.

The American Journal of Physiology
|May 1, 1988
PubMed
Summary

Newborn piglets rely on metabolic factors for intestinal vasoregulation, unlike older animals where myogenic mechanisms dominate. This study reveals age-related shifts in vascular response to elevated venous pressure.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Leukocyte-mediated tissue injury in ischemic stroke.

Current medicinal chemistry·2013
Same author

Microvascular thrombosis and CD40/CD40L signaling.

Journal of thrombosis and haemostasis : JTH·2010
Same author

Role of LPS in the hepatic microvascular dysfunction elicited by cecal ligation and puncture in mice.

Journal of hepatology·2007
Same author

Increased chymotrypsin-like protease (chymase) expression and activity in placentas from women with preeclampsia.

Placenta·2006
Same author

Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis.

American journal of physiology. Gastrointestinal and liver physiology·2006
Same author

Protease chymotrypsin mediates the endothelial expression of P- and E-selectin, but not ICAM and VCAM, induced by placental trophoblasts from pre-eclamptic pregnancies.

Placenta·2003

Area of Science:

  • Physiology
  • Vascular Biology
  • Neonatal Medicine

Background:

  • Local vasoregulation involves metabolic and myogenic mechanisms.
  • Venous pressure elevation is a key factor in understanding these mechanisms.
  • The intestinal vasculature's response changes with age.

Purpose of the Study:

  • To investigate the effects of elevated venous pressure on intestinal hemodynamics and oxygenation in piglets of different ages.
  • To determine the predominant vasoregulatory mechanisms (metabolic vs. myogenic) in the neonatal and older intestinal vasculature.

Main Methods:

  • Studied 20 piglets aged 1-day, 3-day, 2-wk, and 1-mo.
  • Established a venous circuit between the superior mesenteric and jugular veins.
  • Measured superior mesenteric blood flow, venous pressure, capillary pressure, and arteriovenous oxygen difference at varying venous pressures (0-20 mmHg).

Related Experiment Videos

Main Results:

  • Resting intestinal oxygen uptake was higher in 1-day-old piglets compared to older groups.
  • Neonatal piglets showed reduced vascular resistance and increased oxygen uptake upon venous pressure elevation.
  • Older piglets exhibited increased vascular resistance and reduced oxygen uptake in response to venous pressure elevation.

Conclusions:

  • Metabolic factors are dominant in the intestinal vasculature of newborn piglets.
  • Myogenic factors become predominant in the intestinal vasculature of older piglets.
  • Age significantly influences the vasoregulatory mechanisms in response to venous pressure changes.