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A comparison of LISA versus InSurE: A single center experience
T Queliz1,2, J A Perez3,4, M J Corrigan1
1Orlando Health Winnie Palmer Hospital for Women & Babies, Alexander Center for Neonatology, USA.
Journal of Neonatal-Perinatal Medicine
|March 1, 2021
Summary
Less Invasive Surfactant Administration (LISA) did not significantly alter bronchopulmonary dysplasia (BPD) rates in preterm infants compared to the Intubation Surfactant Extubation (InSurE) method. Both surfactant replacement therapy (SRT) approaches showed similar BPD outcomes.
Area of Science:
- Neonatal Medicine
- Pediatric Pulmonology
- Respiratory Care
Background:
- Less invasive surfactant replacement therapy (SRT) methods are associated with improved respiratory outcomes in neonates.
- Bronchopulmonary dysplasia (BPD) remains a significant concern for preterm infants.
Purpose of the Study:
- To evaluate if Less Invasive Surfactant Administration (LISA) impacts the incidence of BPD in preterm infants.
- To compare respiratory outcomes and hospital course between LISA and Intubation Surfactant Extubation (InSurE) methods.
Main Methods:
- Retrospective chart review comparing two groups of preterm infants (25-32 weeks gestation).
- Group 1 received SRT via InSurE; Group 2 received SRT via LISA.
Main Results:
- No significant difference in BPD rates was observed between the LISA and InSurE groups (30.6% vs 33.3%, P=0.47).
- This finding was consistent across preterm infants born between 25-32 weeks gestation.
Conclusions:
- Preterm infants remain at high risk for BPD despite the use of LISA.
- LISA presents a promising, safe, and less invasive alternative to traditional SRT methods like InSurE.
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