Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

308
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
308
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

137
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
137
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

347
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
347
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

531
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
531
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

418
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
418
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

271
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
271

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hepatocellular carcinoma in southern Germany: epidemiological and clinicopathological characteristics and risk factors.

Digestive diseases (Basel, Switzerland)·2002
Same author

Kidney function and glomerulopathy over 8 years in young patients with Type I (insulin-dependent) diabetes mellitus and microalbuminuria.

Diabetologia·2002
Same author

Massive steatosis hepatis: an unusual manifestation of Whipple's disease.

The American journal of gastroenterology·2002
Same author

Naftidrofuryl in the treatment of vascular dementia.

European archives of psychiatry and clinical neuroscience·2002
Same author

Influence of nonylphenol on the microbial community of lake sediments in microcosms.

The Science of the total environment·2002
Same author

[Diagnosis of pancreas tumors: MRI or multidetector spiral CT?].

Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress·2002
Same journal

[Connective (tissue) pathology: What brings us together!]

Der Pathologe·2022
Same journal

[Giant cell-containing tumors of bone and differential diagnoses].

Der Pathologe·2022
Same journal

[Automation and application of robotics in the pathology laboratory].

Der Pathologe·2022
Same journal

[Practical diagnostic aspects of uterine leiomyosarcoma in the context of the 2020 WHO classification].

Der Pathologe·2022
Same journal

[Artificial intelligence: a solution for the lack of pathologists?]

Der Pathologe·2022
Same journal

[Predictive immunocytochemistry in non-small cell lung carcinoma].

Der Pathologe·2022
See all related articles

Related Experiment Video

Updated: Nov 15, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.1K

COVID-19 effects on the kidney.

K Amann1, P Boor2, T Wiech3

  • 1Department of Nephropathology, University Clinic Erlangen, Krankenhausstr. 8-10, 91054, Erlangen, Germany. Kerstin.Amann@uk-erlangen.de.

Der Pathologe
|March 1, 2021
PubMed
Summary
This summary is machine-generated.

Acute kidney injury (AKI) is a severe complication of coronavirus disease 2019 (COVID-19), affecting vulnerable kidney patients. Research is ongoing to understand the virus

Keywords:
Acute kidney injuryCoronavirus infectionsElectron microscopyNeutrophil extracellular traps (NETs)SARS-CoV‑2

More Related Videos

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

435
Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
07:58

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

9.1K

Related Experiment Videos

Last Updated: Nov 15, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.1K
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

435
Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
07:58

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

9.1K

Area of Science:

  • Nephrology
  • Virology
  • Pathophysiology

Background:

  • Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV‑2) infection causes acute kidney injury (AKI), a frequent and severe complication of coronavirus disease 2019 (COVID-19).
  • The renal system is a target for SARS-CoV‑2, with the virus detected in kidney tissue.
  • Patients with chronic kidney disease (CKD), on dialysis, or who have received renal transplants are particularly vulnerable to COVID-19 renal complications.

Purpose of the Study:

  • To analyze the pathophysiology, morphology, and virus detection methods in the kidneys of COVID-19 patients.
  • To review existing autopsy and kidney biopsy data on renal involvement in COVID-19.
  • To clarify the role of direct and indirect viral effects on kidney injury during COVID-19.

Main Methods:

  • Review of autopsy and kidney biopsy studies.
  • Analysis of SARS-CoV‑2 RNA detection in renal tissue.
  • Discussion of electron microscopy findings and associated artifacts for virus visualization.

Main Results:

  • SARS-CoV‑2 RNA detection in kidney tissue yields reproducible results.
  • Electron microscopy for virus visualization is challenging and debated due to artifacts.
  • The precise contribution of direct versus indirect mechanisms of kidney injury in COVID-19 remains under investigation.

Conclusions:

  • AKI is a significant complication of COVID-19, especially in patients with pre-existing kidney conditions.
  • Further research is essential to elucidate the complex mechanisms underlying COVID-19-associated kidney injury.
  • Standardized methodologies for virus detection and morphological analysis are crucial for advancing understanding.