Clinical imaging of marrow adiposity

Area of Science:

• Biomedical Imaging
• Endocrinology
• Bone Metabolism

Background:

• Bone marrow adipose tissue (BMAT) research has significantly grown in the last 20 years.
• BMAT plays a key role in bone loss and endocrine disorders.
• In vivo assessment of BMAT is crucial for understanding its role.

Purpose of the Study:

• To review current imaging methods for assessing bone marrow adipose tissue (BMAT).
• To discuss the clinical applications of these BMAT imaging techniques.

Main Methods:

• Conventional magnetic resonance imaging (MRI)
• Water-fat imaging
• Single-voxel proton magnetic resonance spectroscopy (¹H-MRS)
• Computed tomography (CT)-based techniques (single and dual energy CT)

Main Results:

• The review details various MRI and CT techniques for BMAT quantification and composition analysis.
• These methods enable non-invasive in vivo assessment of BMAT.
• The discussion includes the utility of these techniques in specific clinical contexts.

Conclusions:

• Advanced imaging techniques provide valuable tools for studying bone marrow adipose tissue (BMAT).
• Understanding BMAT through imaging aids in managing bone loss and endocrine disorders.
• Further research utilizing these methods will enhance clinical applications.