Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same authorSame journal

The second Cryptosporidium meeting: Edinburgh's parasite deep dive.

Trends in parasitology·2026

Same author

AI-Accelerated Structure Elucidation of Boavistamides A-C, Cyclic Depsipeptides from a Marine Filamentous Cyanobacterium Collected in Cabo Verde.

bioRxiv : the preprint server for biology·2026

Same author

AI-Accelerated Structure Elucidation of Boavistamides A<b>-</b>C, Cyclic Depsipeptides from a Marine Filamentous Cyanobacterium Collected in Cabo Verde.

Journal of natural products·2026

Same author

A role for the poly-asparagine repeat in the Plasmodium histone acetyltransferase, PfGCN5.

Nature communications·2026

Same author

Structure-Guided Optimization of Novel Inhibitors of <i>Plasmodium</i> Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites.

Journal of medicinal chemistry·2026

Same author

Structure-guided design of calcium-dependent protein kinase 1 (CDPK1) inhibitors for cryptosporidiosis.

The Journal of infectious diseases·2026

Same journal

Hidden diversity in Trichuris control.

Trends in parasitology·2026

Same journal

Evolution of generalism under Muller's ratchet.

Trends in parasitology·2026

Same journal

Next generation in parasitology 2026: Connecting young parasitologists across Europe.

Trends in parasitology·2026

Same journal

Disrupted barriers, evolved risks: toward precision One Health in arthropod allergy.

Trends in parasitology·2026

Same journal

Unveiling malaria history using ancient genomes.

Trends in parasitology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 15, 2025

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

MalDA, Accelerating Malaria Drug Discovery.

Tuo Yang¹, Sabine Ottilie¹, Eva S Istvan²

¹Department of Pediatrics, School of Medicine, University of California, San Diego (UCSD), La Jolla, CA 92093, USA.

Trends in Parasitology

|March 2, 2021

Summary

This summary is machine-generated.

The Malaria Drug Accelerator (MalDA) consortium identifies new antimalarial drug targets and lead inhibitors. By sharing resources, MalDA accelerates the discovery of novel treatments for malaria.

Keywords:

MalDA Plasmodium falciparum drug resistance malaria target-based drug discovery

More Related Videos

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Published on: November 22, 2024

A Multi-detection Assay for Malaria Transmitting Mosquitoes

A Multi-detection Assay for Malaria Transmitting Mosquitoes

Published on: February 28, 2015

Related Experiment Videos

Last Updated: Nov 15, 2025

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Published on: November 22, 2024

A Multi-detection Assay for Malaria Transmitting Mosquitoes

A Multi-detection Assay for Malaria Transmitting Mosquitoes

Published on: February 28, 2015

Area of Science:

Drug Discovery and Development
Parasitology
Medicinal Chemistry

Background:

Malaria remains a significant global health challenge, necessitating novel therapeutic strategies.
Existing antimalarial drug discovery pipelines face numerous structural and biological barriers.
The Malaria Drug Accelerator (MalDA) was established to address these challenges.

Purpose of the Study:

To accelerate the early-stage discovery of antimalarial drugs.
To identify novel, essential, and druggable targets for malaria intervention.
To generate early-stage lead inhibitors for preclinical and clinical development.

Main Methods:

Collaborative research across 15 leading scientific laboratories.
Resource sharing, including expertise, knowledge, materials, and reagents.
Chemical and biological validation of identified drug targets.

Main Results:

Identification of new chemically validated antimalarial targets.
Identification of new biologically validated antimalarial targets.
Progress in generating early lead inhibitors for antimalarial drug candidates.

Conclusions:

The Malaria Drug Accelerator (MalDA) consortium effectively accelerates antimalarial drug discovery.
Collaborative resource sharing overcomes key barriers in early-stage drug development.
Future directions include advancing identified leads into clinical development.