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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
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Clinical crosstalk between microRNAs and gastric cancer (Review)

Jing Ouyang1, Zhizhong Xie1, Xiaoyong Lei1

  • 1Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan 421001, P.R. China.

International Journal of Oncology
|March 2, 2021
PubMed

Insights

MicroRNAs (miRNAs) play a crucial role in gastric cancer (GC) development and progression. This review explores recent findings on miRNA mechanisms for potential clinical applications in diagnosing and treating this deadly disease.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Gastric cancer (GC) is a significant global health challenge, ranking as the sixth most common and third deadliest cancer worldwide.
  • MicroRNAs (miRNAs), small non-coding RNA molecules, regulate gene expression post-transcriptionally and are increasingly implicated in various diseases.

Purpose of the Study:

  • To review and summarize recent (past three years) research on microRNAs (miRNAs) mechanistically linked to gastric cancer (GC).
  • To explore the potential clinical applications of these miRNAs in GC diagnosis, treatment, and prognosis.

Main Methods:

  • Literature review focusing on studies published within the last three years.
  • Analysis of confirmed mechanisms of action for miRNAs involved in gastric cancer.
  • Synthesis of findings to predict clinical utility.

Main Results:

  • Numerous microRNAs (miRNAs) have been identified with confirmed roles in the oncogenesis, development, diagnosis, treatment, and prognosis of gastric cancer (GC).
  • Despite extensive research, few miRNAs have translated into clinical practice for GC management.

Conclusions:

  • Understanding the specific mechanisms of action of recently identified gastric cancer-associated miRNAs is crucial.
  • These miRNAs hold promise for novel clinical applications, offering new strategies to overcome gastric cancer.
Keywords:
gastric cancermicroRNAsclinical applications

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