Related Experiment Video

Updated: Nov 15, 2025

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

4.2K

Mean Platelet Volume/Platelet Count Ratio and Culprit Plaque Morphologies: An Optical Coherence Tomography Study in

Li Song1, Run-Zhen Chen1, Xiao-Xiao Zhao1

  • 1Coronary Heart Disease Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, No. 167, Beilishi Road, Beijing, 100037, China.

Journal of Cardiovascular Translational Research
|March 2, 2021
PubMed

Insights

The mean platelet volume/platelet count ratio (MPR) can predict plaque rupture in ST-segment elevation myocardial infarction (STEMI) patients. Higher MPR values independently indicate plaque rupture, improving diagnostic accuracy.

Area of Science:

  • Cardiology
  • Hematology
  • Biomarkers

Background:

  • ST-segment elevation myocardial infarction (STEMI) is a critical cardiovascular event.
  • Identifying coronary plaque features is crucial for risk stratification in STEMI patients.
  • Platelet indices are increasingly recognized as potential biomarkers in cardiovascular disease.

Purpose of the Study:

  • To evaluate the predictive value of the mean platelet volume/platelet count ratio (MPR) for coronary plaque rupture (PR) versus plaque erosion (PE) in STEMI patients.
  • To compare the diagnostic performance of MPR against other platelet indices for identifying PR.
  • To assess the incremental value of MPR in predicting PR when combined with established risk factors.

Main Methods:

  • A cohort of 275 STEMI patients undergoing pre-PCI optical coherence tomography (OCT) was analyzed.
  • Patients were classified into plaque rupture (PR) and plaque erosion (PE) groups.
  • Multivariable logistic regression and receiver operating characteristic (ROC) curve analysis were employed to assess MPR's predictive and diagnostic capabilities.

Main Results:

  • Higher MPR was identified as an independent predictor of PR (tertile 3 vs. tertile 1, OR: 6.257, P=0.009).
  • MPR demonstrated superior diagnostic performance for PR compared to other platelet indices, with an optimal threshold of 0.0473 (Sensitivity: 72.1%, Specificity: 64.7%).
  • Incorporating MPR into established risk factor models significantly improved the prediction of PR (AUC: 0.767 vs. 0.722, Pdifference=0.004).

Conclusions:

  • MPR serves as an independent predictor of plaque rupture in STEMI patients.
  • MPR enhances the diagnostic performance for identifying plaque rupture in this population.
  • MPR offers valuable prognostic information and may aid in risk stratification for STEMI.

Keywords:
Plaque ruptureST segment elevation myocardial infarctionmean platelet volume/platelet count ratio

More Related Videos

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

296
Microfluidics in Assessing Platelet Function06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.3K

Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
181
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
86
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
212