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Comorbidities in patients with chronic hepatitis C and hepatitis B on hemodialysis

Po-Yao Hsu1,2, Yu-Ju Wei1,2, Po-Cheng Liang2

  • 1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Journal of Gastroenterology and Hepatology
|March 2, 2021
PubMed

Insights

Hemodialysis patients often have multiple health issues. Those with Hepatitis C virus (HCV) infection experience a greater number of comorbidities, particularly heart and respiratory conditions, compared to Hepatitis B virus (HBV) or no viral hepatitis patients.

Area of Science:

  • Nephrology
  • Hepatology
  • Infectious Diseases

Background:

  • Hemodialysis patients face elevated risks of Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infections.
  • These viral infections can lead to severe liver disease and conditions affecting organs beyond the liver.

Purpose of the Study:

  • To compare the prevalence and types of hepatic and extrahepatic comorbidities in hemodialysis patients with HBV or HCV infections versus those without viral hepatitis.

Main Methods:

  • A cohort of 1910 hemodialysis patients was analyzed, categorized into HCV viremic (HCV group), HBV surface antigen positive (HBV group), and seronegative for both (non-B and non-C [NBNC] group).
  • Comorbidities were identified and classified using the International Classification of Diseases-10th Revision (ICD-10).

Main Results:

  • Nearly all patients (96%) had at least one comorbidity, with an average of 2.9 per person. Hypertension, diabetes, and ischemic heart diseases were most common.
  • HCV patients showed a significantly higher mean number of comorbidities (3.3) compared to HBV (2.7) and NBNC (2.9) groups.
  • This difference was primarily driven by increased rates of ischemic heart disease, respiratory disorders, and mental/behavioral disorders in the HCV group.

Conclusions:

  • Hemodialysis patients exhibit a high burden of multiple comorbidities.
  • HCV infection in hemodialysis patients is associated with a greater comorbidity load, notably cardiovascular, respiratory, and mental health conditions, compared to HBV infection or absence of viral hepatitis.
Abstract

Keywords:
comorbiditieshemodialysishepatitis B virushepatitis C virus

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