Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pharyngitis01:23

Chronic Pharyngitis

7.9K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
7.9K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

426
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
426
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

631
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
631
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

4.7K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.7K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

308
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
308
Allergic Reactions02:06

Allergic Reactions

30.0K
Overview
30.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AI-Powered Imaging for Objective Psoriasis Severity Assessment at Home: Feasibility and Reliability in a Randomized Clinical Trial.

Journal of the American Academy of Dermatology·2026
Same author

Exploring novel skin biomarkers related to pruritus in dialysis patients.

International urology and nephrology·2026
Same author

Prayer sign as a marker of disease severity and treatment response in eosinophilic fasciitis: A case series.

JAAD case reports·2026
Same author

Remote monitoring in chronic immune-mediated inflammatory diseases: A systematic review of active and passive approaches.

JAAD international·2026
Same author

[Vitiligo].

Nederlands tijdschrift voor geneeskunde·2025
Same author

Topical Steroid Withdrawal: Perspectives of Dutch Healthcare Professionals.

Acta dermato-venereologica·2025
Same journal

[Insulin intoxications caused by falsified semaglutide].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[Professional skepticism in medical research].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[Improving mobility in painful osteoarthritis].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[The effectiveness and costs of the Back At work After Surgery (BAAS) work-integrated care pathway on return to work for patients receiving knee arthroplasty].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[The rise of genetic therapies: urgent moral and societal questions].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[A man with a wound on his elbow].

Nederlands tijdschrift voor geneeskunde·2026
See all related articles

Related Experiment Video

Updated: Nov 15, 2025

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

12.7K

[Chronic itch].

Deepak M W Balak1, Patrick M J H Kemperman2, H B Thio3,4

  • 1LangeLand Ziekenhuis, afd. Dermatologie, Zoetermeer.

Nederlands Tijdschrift Voor Geneeskunde
|March 2, 2021
PubMed
Summary
This summary is machine-generated.

Chronic itch lasting over six weeks is a significant health issue. Identifying the cause is key, and a multimodal approach is preferred for chronic itch of unknown origin.

More Related Videos

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

4.3K
Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
03:40

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

Published on: April 25, 2025

955

Related Experiment Videos

Last Updated: Nov 15, 2025

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

12.7K
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

4.3K
Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
03:40

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

Published on: April 25, 2025

955

Area of Science:

  • Dermatology
  • Internal Medicine
  • Neurology
  • Psychiatry

Background:

  • Chronic itch, persisting >6 weeks, presents a substantial disease burden.
  • It can stem from skin conditions, internal diseases, neurologic disorders, psychiatric conditions, or medications.
  • Identifying the etiology is crucial for effective chronic itch management.

Purpose of the Study:

  • To outline diagnostic and management strategies for chronic itch, particularly when the origin is unknown.

Main Methods:

  • Detailed patient history and physical examination are essential.
  • Initial laboratory screening is recommended for generalized chronic itch without primary skin lesions.
  • Further investigations should be guided by clinical suspicion.

Main Results:

  • In 8% of cases, no underlying cause for chronic itch is identified, termed pruritus of unknown origin.
  • Diagnostic work-up involves a systematic approach based on clinical presentation.

Conclusions:

  • Management of chronic itch requires determining the underlying cause.
  • For pruritus of unknown origin, a multimodal treatment strategy is recommended.