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Updated: Nov 15, 2025

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
Therapeutic interventions and mechanisms associated with gut microbiota-mediated modulation of immune checkpoint
Matthew K Wong1, Philip Barbulescu1, Bryan Coburn2
1Department of Immunology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
Abstract:
The link between the gut microbiome and responsiveness to immune checkpoint inhibitor (ICI) therapy is now well established. New therapeutic opportunities exploiting this relationship are being developed with the goal of augmenting ICI efficacy. In this review, we summarize the foundational research establishing these interactions and discuss the mechanisms and novel therapeutic options associated with this gut microbiome-ICI connection.
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