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Type 2 Diabetes Prevention Focused on Normalization of Glycemia: A Two-Year Pilot Study
Amy L McKenzie1, Shaminie J Athinarayanan1, Jackson J McCue2
1Virta Health, San Francisco, CA 94105, USA.
Nutrients
|March 3, 2021
Summary
A remote care intervention using carbohydrate-restricted nutrition therapy effectively prevented type 2 diabetes in prediabetes patients. This approach normalized blood sugar and improved related health conditions over two years.
Area of Science:
- Endocrinology and Metabolic Diseases
- Nutrition Science
- Preventive Medicine
Background:
- Prediabetes poses a significant risk for developing type 2 diabetes.
- Lifestyle interventions are crucial for diabetes prevention.
- Continuous remote care models offer scalable solutions for chronic disease management.
Purpose of the Study:
- To evaluate a continuous remote care intervention for type 2 diabetes prevention.
- To assess the impact of carbohydrate-restricted nutrition therapy on glycemic control.
- To determine the efficacy of this approach in patients with prediabetes.
Main Methods:
- A two-year, single-arm, prospective pilot study.
- Ninety-six participants with prediabetes received remote care focused on carbohydrate restriction.
- Blood beta-hydroxybutyrate levels monitored adherence to nutritional goals.
Main Results:
- Two-year retention rate was 75%.
- Estimated cumulative incidence of normoglycemia was 52.3%; type 2 diabetes incidence was 3%.
- Significant reductions in metabolic syndrome, obesity, and suspected hepatic steatosis were observed.
Conclusions:
- Carbohydrate-restricted nutrition therapy via continuous remote care shows promise for type 2 diabetes prevention.
- This intervention can normalize glycemia and improve associated comorbidities.
- The model demonstrates potential for widespread application in diabetes prevention programs.
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