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When MARCH family proteins meet viral infections

Chunfu Zheng1,2, Yan-Dong Tang3

  • 1Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China. zheng.alan@hotmail.com.

Virology Journal
|March 3, 2021
PubMed

Insights

Membrane-associated RING-CH (MARCH) ubiquitin ligases are crucial in viral infections. These proteins can hinder or help viral replication, and recent research highlights their complex roles.

Area of Science:

  • Biochemistry
  • Virology
  • Molecular Biology

Background:

  • Membrane-associated RING-CH (MARCH) proteins are E3 ubiquitin ligases.
  • MARCH proteins are implicated in diverse cellular processes.
  • Their roles in viral pathogenesis are increasingly recognized.

Purpose of the Study:

  • To review recent advances in understanding MARCH proteins during viral infections.
  • To highlight the dual role of MARCH proteins in viral life cycles.
  • To consolidate current knowledge on MARCH family proteins in virology.

Main Methods:

  • Literature review of recent studies on MARCH proteins and viral infections.
  • Analysis of experimental data on MARCH protein function in viral pathogenesis.
  • Synthesis of findings on MARCH protein interactions with viral components.

Main Results:

  • MARCH proteins exhibit diverse functions in viral infections.
  • They can act as antiviral factors by targeting viral proteins for degradation.
  • Conversely, some MARCH proteins can promote viral entry or replication.

Conclusions:

  • MARCH ubiquitin ligases are key regulators of viral infections.
  • Targeting MARCH proteins offers potential therapeutic strategies against viruses.
  • Further research is needed to fully elucidate MARCH protein functions in different viral systems.
Keywords:
AntiviralE3 ligaseMARCHProviralRING finger

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