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Published on: May 28, 2014
Morpholine- and Thiomorpholine-Based Amidodithiophosphonato Nickel Complexes: Synthesis, Characterization, P-N
Enrico Podda1, M Carla Aragoni1, Massimiliano Arca1
1Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, Cittadella Universitaria, SS. 554 Bivio Sestu, 09042 Monserrato - Cagliari, Italy.
Abstract:
The reactivity of thiomorpholinium P-(4-methoxyphenyl)-N-thiomorpholin-amidodithiophosphonate (S-MorH and morpholinium P-(4-methoxyphenyl)-N-morpholin-amidodithiophosphonate (O-MorH towards nickel (II) dichloride hexahydrated is presented and the hydrolysis of the relevant metal complexes investigated. The hydrolytic products (S-MorH+₂)₂ [Ni(dtp)₂]²- and (O-MorH+₂)₂[Ni(dtp)₂]²- were characterized by means of FT-IR, 1H, and 31P NMR and XRD and the experimented P-N cleavage investigated and elucidated by means of DFT calculations. The antimicrobial activity of the neutral nickel complex [Ni(S-Mor-adtp)₂] was tested against a set of Gram-positive and Gram-negative bacteria alongside with its nanodispersion in a silica matrix. The complex [Ni(S-Mor-adtp)₂] did not show antibacterial activity, whilst the nano-dispersed sample [Ni(S-Mor-adtp)₂]_SiO₂ demonstrated inhibition to growth of Staphylococcus aureus. The nanocomposites were fully characterized by means of XRPD, TGA, SEM and dinitrogen sorption techniques.
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