Related Experiment Video
Updated: Nov 15, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Hierarchical Core-Shell Fe₃O₄@mSiO₂@Chitosan Nanoparticles for pH-Responsive Drug Delivery
Ning Zhang1, Chengzheng Jia1, Xingyue Ma1
1Department of Chemistry, College of Science, University of Shanghai for Science and Technology, Shanghai 200093, China.
Abstract:
Hierarchical nanoparticles are of great interest because they possess unique physicochemical properties and multiple functionalities, providing a wealth of possibilities for various applications. In this work, we have developed a well-designed method to prepare hierarchical magnetic nanoparticles Fe₃O₄@mSiO₂@CS by integrating a solvothermal method for synthesizing the Fe₃O₄ core, a dualtemplating micelle system for preparing a layer of mesoporous silica (mSiO₂) shell, and a silane coupling method via γ-glycidoxypropyltrimethoxysilane for binding a chitosan (CS) layer on the silica surface. The porous hierarchical nanoparticles were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), dynamic light scattering nanoparticle size analyzer, and specific surface area and pore size analyzer. The loading capacity and the release behavior of the as-prepared nanoparticles for doxorubicin hydrochloride were studied, and it was found that the drug release rate was faster at pH 6.0 than at pH 7.4, revealing the pH-responsive property of the nanoparticles.
Related Concept Videos
Drug Delivery: Overview
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Bioavailability Enhancement: Drug Solubility Enhancement
Bioavailability Enhancement: Drug Permeability Enhancement
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...

