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Related Experiment Video

Updated: Nov 15, 2025

High-resolution Measurement of Odor-Driven Behavior in Drosophila Larvae

High-resolution Measurement of Odor-Driven Behavior in Drosophila Larvae

Published on: January 3, 2008

Optogenetic Food Odor Avoidance Assay.

Jay M Patel^1,2, Jessica Swanson³, Benjamin R Arenkiel^1,2,3,4

¹Department of Neuroscience, Baylor College of Medicine, Houston, USA.

|March 3, 2021

Summary

This summary is machine-generated.

Researchers explored how brain circuits process sensory food cues to influence appetite. They found that stimulating specific basal forebrain neurons altered feeding behavior in mice, offering insights into appetite control.

Keywords:

Circuit Feeding Mouse Neuroscience Olfactory Optogenetics

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Last Updated: Nov 15, 2025

High-resolution Measurement of Odor-Driven Behavior in Drosophila Larvae

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Published on: January 3, 2008

A Single-fly Assay for Foraging Behavior in Drosophila

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Published on: November 4, 2013

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Published on: June 12, 2014

Area of Science:

Neuroscience
Sensory Processing
Appetite Regulation

Background:

Appetite is influenced by sensory food experiences, extending beyond basic energy needs.
Hypothalamic feeding circuits respond to food-related sensory cues, but underlying mechanisms remain unclear.
Excitatory basal forebrain neurons are implicated in appetite suppression and odorant responses.

Purpose of the Study:

To investigate the neural circuit mechanisms by which sensory information influences feeding behavior.
To determine if basal forebrain neuron stimulation affects sensory modulation of appetite.
To establish a paradigm for studying the role of specific circuits in appetitive and aversive behaviors.

Main Methods:

Stereotaxic viral targeting of Cre-dependent channelrhodopsin in basal forebrain.
Fiber optic cannula implantation for targeted photostimulation.
Odor-associated learning paradigm in mice followed by behavioral analysis during photostimulation.

Main Results:

Mice were trained to associate a specific odor with food.
Photostimulation of basal forebrain neurons modulated behavioral responses to odors.
Behavioral tracking quantified changes in odor investigation time, indicating altered feeding behavior.

Conclusions:

The study highlights the role of basal forebrain circuitry in integrating sensory cues and modulating appetite.
This research provides a framework for dissecting neural circuits involved in feeding behavior.
Findings contribute to understanding how sensory perception influences eating beyond homeostatic regulation.