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Antiangiogenic therapy in diabetic nephropathy: A double‑edged sword (Review)
Qian-Ru Tao1, Ying-Ming Chu2, Lan Wei3
1Department of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, P.R. China.
Abstract:
Diabetes and the associated complications are becoming a serious global threat and an increasing burden to human health and the healthcare systems. Diabetic nephropathy (DN) is the primary cause of end‑stage kidney disease. Abnormal angiogenesis is well established to be implicated in the morphology and pathophysiology of DN. Factors that promote or inhibit angiogenesis serve an important role in DN. In the present review, the current issues associated with the vascular disease in DN are highlighted, and the challenges in the development of treatments are discussed.
Insights
Diabetic nephropathy (DN) is a major cause of kidney failure, linked to abnormal blood vessel growth. Understanding factors affecting angiogenesis is key to developing new treatments for this diabetes complication.
Area of Science:
- Nephrology
- Vascular Biology
- Endocrinology
Background:
- Diabetes mellitus presents a growing global health challenge with severe complications.
- Diabetic nephropathy (DN) is the leading cause of end-stage kidney disease worldwide.
- Aberrant angiogenesis plays a critical role in the development and progression of DN.
Purpose of the Study:
- To review current challenges in vascular disease within diabetic nephropathy.
- To discuss the role of angiogenesis in DN pathophysiology.
- To highlight obstacles in developing effective DN treatments.
Main Methods:
- Literature review of current research on DN and angiogenesis.
- Analysis of factors influencing vascular changes in diabetic kidneys.
- Discussion of therapeutic strategies targeting angiogenesis in DN.
Main Results:
- Abnormal angiogenesis is a key feature in the progression of diabetic nephropathy.
- Factors modulating angiogenesis significantly impact DN.
- Current treatment development faces challenges related to vascular complications in DN.
Conclusions:
- Targeting angiogenesis is a potential therapeutic avenue for DN.
- Further research is needed to overcome challenges in developing anti-angiogenic or pro-angiogenic therapies for DN.
- Addressing vascular disease is crucial for managing diabetic nephropathy.
