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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
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Schizophrenia during pregnancy
1Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Current Opinion in Psychiatry
|March 3, 2021
Summary
Women with schizophrenia face unique challenges during pregnancy, including reproductive health and medication management. Research is needed to improve care and outcomes for pregnant women with schizophrenia and their infants.
Area of Science:
- Reproductive Psychiatry
- Perinatal Mental Health
- Schizophrenia Spectrum Disorders
Background:
- Schizophrenia diagnosis impacts childbearing-aged women's sexual health, psychopharmacological treatment, and pregnancy outcomes.
- Pregnancy rates are increasing but remain lower than in the general population, with higher rates of induced abortions.
Purpose of the Study:
- To review recent literature on the implications of schizophrenia in women of childbearing age.
- To focus on sexual health, psychopharmacological treatment, and pregnancy/fetal outcomes.
Main Methods:
- A narrative review of recent scientific papers.
- Focus on recent findings and current evidence.
Main Results:
- Antipsychotic use in pregnancy is increasing, with evidence suggesting safety.
- Drug level monitoring is recommended due to pregnancy-related physiological changes.
- Increased risk of gestational diabetes, adverse obstetric, and infant outcomes necessitates vigilant physical health monitoring.
Conclusions:
- There is an urgent need for research to develop effective treatment and relapse-prevention protocols.
- Interventions should focus on pharmaceutical targets to benefit pregnant women with schizophrenia, their families, and children.
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