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Updated: Nov 15, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
[Types of evidence syntheses]
S Graf1,2, J Kranz3,4,5, S Schmidt3
1Klinik für Urologie und Andrologie, Kepler Universitätsklinikum Linz, Krankenhausstraße 9, 4020, Linz, Österreich. sebastian.graf@kepleruniklinikum.at.
Abstract:
This manuscript outlines various types of review articles as forms of evidence synthesis with special regard to their strengths and limitations. Review articles not only present summarised data, but also offer an evaluation of the quality of the individual studies included in it. The validity and the reliability of outcomes of reviews is strongly dependent on the quality of the data included. For this reason, a comprehensive literature selection process is paramount. Fundamental knowledge of bias and literature assessment is also necessary when reading reviews. This article presents selected tools for evidence appraisal and evaluation of bias risk.
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