Direct mapping from diffuse reflectance to chromophore concentrations in multi-f spatial frequency domain imaging...

Spatial frequency domain imaging (SFDI) is an emerging technology that enables label-free, non-contact, and wide-field mapping of tissue chromophore contents, such as oxy- and deoxy-hemoglobin concentrations. It has been shown that the use of more than two spatial frequencies (multi-f ) can vastly improve measurement accuracy and reduce chromophore estimation uncertainties, but real-time multi-f SFDI for chromophore monitoring has been limited in practice due to the slow speed of available chromophore inversion algorithms. Existing inversion algorithms have to first convert the multi-f diffuse reflectance to optical absorptions, and then solve a set of linear equations to estimate chromophore concentrations. In this work, we present a deep learning framework, noted as a deep residual network (DRN), that is able to directly map from diffuse reflectance to chromophore concentrations. The proposed DRN is over 10x faster than the state-of-the-art method for chromophore inversion and enables 25x improvement on the frame rate for in vivo real-time oxygenation mapping. The proposed deep learning model will help enable real-time and highly accurate chromophore monitoring with multi-f SFDI.