Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

7.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
7.2K
Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

3.6K
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
3.6K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

263
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
263
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

3.7K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.7K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

135
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
135
Cancer Survival Analysis01:21

Cancer Survival Analysis

522
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
522

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nutritional Risk Screening in Gynaecologic Oncology Surgery: Importance, Scoring Systems, Recommendations and Practical Applications.

Journal of clinical medicine·2026
Same author

Automated extraction of ESGO operative report fields from free-text surgical notes using large language models in advanced ovarian cancer.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2026
Same author

Trifluridine/tipiracil (FTD/TPI) in advanced gastric cancer-a retrospective cohort study providing real-world survival and safety data from the United Kingdom.

Journal of gastrointestinal oncology·2026
Same author

Prognostic and immunological significance of tryptophan metabolic enzymes across endometrial cancer molecular subtypes.

Gynecologic oncology·2025
Same author

Smoking Adversely Affects Survival of Metastatic Lung Carcinoid Patients: Analysis of a Large International Audit and Prognostic Models for Metastasis-Free Survival and Overall Survival.

Neuroendocrinology·2025
Same author

Endobronchial malignancy as a manifestation of advanced ovarian cancer recurrence: a case report and literature review.

Translational cancer research·2025

Related Experiment Video

Updated: Nov 15, 2025

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
09:48

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

8.4K

Breast Cancer Patients at Increased Risk of Developing Type II Endometrial Cancer: Relative and Absolute Risk

Sara Portela1, Aimee Cunningham1, Alexandros Laios1

  • 1Gynaecological Oncology, Leeds Teaching Hospitals NHS Trust, Leeds, GBR.

Cureus
|March 4, 2021
PubMed
Summary

Women with breast cancer (BC) face a significantly higher risk of developing endometrial cancer (EC), especially type II EC (T2EC). Tamoxifen use and older age at BC diagnosis are key risk factors, warranting increased screening and consideration of prophylactic hysterectomy.

Keywords:
breast cancer managementendometrial carcinomashysterectomytamoxifen

More Related Videos

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

500
In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
13:04

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose

Published on: October 14, 2015

13.5K

Related Experiment Videos

Last Updated: Nov 15, 2025

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
09:48

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

8.4K
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

500
In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
13:04

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose

Published on: October 14, 2015

13.5K

Area of Science:

  • Oncology
  • Gynecologic Oncology
  • Cancer Epidemiology

Background:

  • Breast cancer (BC) is a known risk factor for endometrial cancer (EC).
  • Literature suggests BC confers a higher risk for type II EC (T2EC) than type I EC (T1EC).
  • Prophylactic hysterectomy is sometimes offered to BC patients but lacks standard evidence.

Purpose of the Study:

  • To quantify the absolute and relative risk (RR) of developing EC subtypes in BC patients.
  • To identify patient subgroups at higher risk for EC who may benefit from prophylactic hysterectomy.

Main Methods:

  • Retrospective service evaluation of BC patients diagnosed between 2008-2014 who developed EC within 10 years.
  • Calculation of absolute risk and RR using regional BC/EC data and UK population statistics.
  • Binary logistic regression to determine adjusted odds ratios (ORs) for patient and disease variables.

Main Results:

  • BC patients had a significantly higher RR of developing EC (RR: 12.44) compared to the general population.
  • The RR was notably higher for T2EC (RR: 33.96) than T1EC (RR: 8.63).
  • Tamoxifen exposure (adjusted OR: 79.61) and increased age at BC diagnosis (adjusted OR: 1.10-1.13) were associated with EC development, particularly T2EC.

Conclusions:

  • Women with BC have a substantially increased risk of T2EC, necessitating vigilance despite low absolute risk.
  • Tamoxifen use is a strong predictor of EC, especially T2EC, aiding risk stratification.
  • Older women with BC on tamoxifen require close EC monitoring; prophylactic hysterectomy counseling should be considered due to T2EC screening limitations.