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Related Experiment Videos

T A Potapova1, A G Romashchenko1, N S Yudin2

  • 1Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Vavilovskii Zhurnal Genetiki I Selektsii
|March 4, 2021
PubMed
Summary
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TRPM8 gene variants show distinct haplotype distributions across Eurasian populations, particularly between Chukchi and Russians. These variations in cold receptor genes may reflect human migration patterns and adaptation.

Area of Science:

  • Human genetics
  • Molecular biology
  • Neuroscience

Context:

  • The TRPM8 gene encodes a cold-sensitive ion channel crucial for neuronal function.
  • Understanding TRPM8 gene diversity is key to comprehending human adaptation to different climates.
  • Previous studies have not fully explored TRPM8 haplotype frequencies in diverse Eurasian populations.

Purpose:

  • To investigate the haplotype distribution of six single nucleotide polymorphisms (SNPs) within the TRPM8 gene across Russian, Kazakh, and Chukchi populations.
  • To identify specific TRPM8 gene variants and their association with geographical populations.
  • To analyze the functional implications of identified TRPM8 variants on protein structure and function.

Summary:

  • Haplotype analysis of six TRPM8 SNPs revealed significant distribution differences among Eurasian populations, with pronounced variations between Chukchi and Russians.
Keywords:
Eurasian human populationsTRPM8 genealternative start codonshaplotypes

Related Experiment Videos

  • The Ser419Asn substitution in the TRPM8 protein, influenced by an SNP in exon 11, showed differing frequencies, being less common in Russians and more prevalent in Chukchi.
  • TRPM8 gene variants associated with Asian populations, including specific SNPs in exon 7, were also identified, with frequencies in Chukchi resembling those in African populations.

    • Impact:

    • This study highlights the genetic diversity of the TRPM8 cold receptor gene across Eurasia.
    • Findings suggest that TRPM8 haplotype variations may be linked to human migration and adaptation processes during the colonization of Eurasia.
    • The identified TRPM8 gene variants provide insights into the molecular basis of cold sensation and neuronal function in different human groups.